Results 181 to 190 of about 7,378 (211)

Inner retina and melanopsin retinal ganglion cells in Parkinson's disease

Acta Ophthalmologica, 2022
AbstractParkinson's disease (PD) is a neurogenerative disorder characterized by sleep and circadian dysfunction.Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive retinal ganglion cells mainly contributing to circadian photoentrainment by projecting to the suprachiasmatic nucleus of the hypothalamus. They also regulate pupillary
Chiara La Morgia, Martina Romagnoli, Michele Carbonelli, Giulia Amore, Valerio Carelli   +4 more
openaire   +1 more source

Melanopsin and non-melanopsin expressing retinal ganglion cells innervate the hypothalamic suprachiasmatic nucleus

Visual Neuroscience, 2003
Retinal input to the hypothalamic suprachiasmatic nucleus (SCN) synchronizes the SCN circadian oscillator to the external day/night cycle. Retinal ganglion cells that innervate the SCNviathe retinohypothalamic tract are intrinsically light sensitive and express melanopsin.
Patricia J, Sollars, Cynthia A, Smeraski, Jessica D, Kaufman, Malcolm D, Ogilvie, Ignacio, Provencio, Gary E, Pickard   +5 more
openaire   +2 more sources

Melanopsin containing retinal ganglion cells are light responsive from birth

NeuroReport, 2004
Photoentrainment of the biological clock located in the suprachiasmatic nucleus (SCN) begins shortly after birth. Here we show using c-FOS immunoreactivity as a marker for neuronal activity that the melanopsin/PACAP containing retinal ganglion cells (RGCs) which project to the SCN as the retinohypothalamic tract (RHT) are responsive to light from birth.
Jens, Hannibal, Jan, Fahrenkrug
openaire   +2 more sources

Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

Journal of Comparative Neurology, 2017
AbstractIntrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin belong to a heterogenic population of RGCs which regulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex, and sleep/wake cycles.
Jens Hannibal, Anders Tolstrup Christiansen, Steffen Heegaard, Jan Fahrenkrug, Jens Folke Kiilgaard   +4 more
openaire   +3 more sources

Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells

European Journal of Neuroscience, 2005
AbstractIn mammals a subpopulation of retinal ganglion cells are intrinsically photosensitive (ipRGCs), express the photopigment melanopsin, and play an important role in the regulation of the nonimage‐forming visual system. We have recently reported that melanopsin mRNA and protein levels in the rat retina are under photic and circadian control.
Katsuhiko, Sakamoto, Cuimei, Liu, Manami, Kasamatsu, Nikita V, Pozdeyev, P Michael, Iuvone, Gianluca, Tosini   +5 more
openaire   +2 more sources

Morphological Identification of Melanopsin-Expressing Retinal Ganglion Cell Subtypes in Mice

2018
Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are a relatively recently discovered class of photoreceptor. ipRGCs can be subdivided into at least five subtypes (M1-M5), each of which has a distinct complement of morphological and physiological properties.
Seul Ki, Lee, Tiffany M, Schmidt
openaire   +2 more sources

Controlling the number of melanopsin-containing retinal ganglion cells by early light exposure

Experimental Eye Research, 2013
A small percentage of retinal ganglion cells (RGCs) express melanopsin and are intrinsically photosensitive (ipRGCs). Whether light can affect the development of ipRGCs is not clear. In the rat retina, we found constant light exposure during the first postnatal week significantly increased the number of melanopsin immunopositive ipRGCs.
Jie, Hong, Qiang, Zeng, Huaizhou, Wang, Debbie S, Kuo, William H, Baldridge, Ningli, Wang   +5 more
openaire   +2 more sources

Melanopsin retinal ganglion cells and circadian dysfunction in Alzheimer´s disease

Acta Ophthalmologica, 2013
AbstractPurpose To evaluate optic nerve and in particular melanopsin retinal ganglion cells (mRGCs) in relation to rest‐activity rhythm in Alzheimer disease (AD).Methods Retinal nerve fiber layer (RNFL) thickness measurements by optical coherence tomography were performed in 21 AD and 74 age‐matched controls.
C. LA MORGIA, R. GALLASSI, L. SAMBATI, F. PROVINI, FN ROSS CISNEROS, B. PAN, P. BARBONI, G. CANTALUPO, J. HANNIBAL, A. SADUN, V. CARELLI, AVANZINI, Pietro   +11 more
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Putative retinal and cortical potentials from melanopsin sensitive ganglion cells

Eye, 2020
Jeff Rabin, Julie Lovell, Neda Tahvilian, Annie Ku, Tayde Contreras, Jessica Carachure, Lydia Geabou, Jared Sies, Dung Nguyen   +8 more
openaire   +2 more sources

A foundation model for generalizable disease detection from retinal images

Nature, 2023
Yukun Zhou, Murat Seçkin Ayhan
exaly