Results 161 to 170 of about 1,036 (190)

Meldonium in Treatment of Patients With Myocardial Infarction

Kardiologiia, 2014
Therapy with meldonium belongs to "metabolic direction" which is developing in cardiovascular medicine. Its purpose is restoration of impaired cellular metabolism.
G I, Nechaeva, D A, Potashov, E N, Zheltikova   +2 more
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Testing Meldonium: Assessing Soviet pragmatic alternatives to the randomized controlled trial

Clinical Trials, 2021
Background/aims Current research largely tends to ignore the drug-testing model that was developed in the “Second World” as an explicit alternative to the randomized controlled trial. This system can be described as “socialist pharmapolitics,” accounting for the specific features of state socialism that influenced the development and testing of ...
Anastasiya Chirkova, Alexander Petrenko, Pavel Vasilyev   +2 more
openaire   +2 more sources

Analytical methods for meldonium determination in urine samples

Analytical Letters, 2020
Here is reported a rapid analytical method for meldonium and other beta blockers (metoprolol, amlodipine, bisoprolol, nebivolol, betaxolol, and carvediol) in urine samples using Fourier transform i...
L. D. Rusu, I. Bratu, C. Măruțoiu, Z. Moldovan, M. Rada   +4 more
openaire   +1 more source

Sixty seconds on . . . meldonium

BMJ, 2016
Yes, definitely a double fault for the Russian tennis star. Meldonium (also known as mildronate) is a drug made in Latvia used for treating heart failure, angina, and myocardial infarction. It isn’t licensed in the United States or Europe. We don’t know, but it seems unlikely. She has said that she had magnesium …
openaire   +1 more source

Chronic cerebrovascular diseases and neuroprotection: the clinical efficacy of meldonium (Mildronat)

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2020
To evaluate the efficacy of meldonium (mildronat) in patients with chronic cerebral vascular disease (CVD).An open comparative study of the clinical efficacy of meldonium (mildronat) in patients with chronic CVD caused by arterial hypertension and atherosclerosis was conducted.
M M, Tanashyan, M Yu, Maksimova, A A, Shabalina, P A, Fedin, R B, Medvedev, T A, Bolotova   +5 more
openaire   +2 more sources

Optoelectronical method for identification of meldonium in urine samples

Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 2018
Meldonium is an anti-ischemia drug developed in 1970 by Ivars Kalvins at the USSR Latvia Institute of organic synthesis. Meldonium is reportedly capable of providing clinical benefit for those suffering from heart conditions, such as low blood flow to the heart and angina, as well as neurodegenerative disorders and bronchopulmonary diseases. It appears
Georgeta Marcela Bican, Mihai Ionica, Mihai Radu, Bogdan Berghes, Jeni -Carla Colev   +4 more
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Efficiency of Meldonium in the Complex Therapy of Acute Coronary Syndrome

Kardiologiia, 2014
We examined 140 patients (mean age 54.8±3.1 years) with ST elevation acute coronary syndrome resulting in Q-wave myocardial infarction of the left ventricle. From the first hours complex therapy of these patients comprised meldonium (1 g/day intravenously for 2 weeks then orally until 1.5 months).
V P, Mikhin, M A, Cherniatina, G V, Panchenko, A V, Kharchenko, Iu A, Tsukanova   +4 more
openaire   +2 more sources

Story behind meldonium–from pharmacology to performance enhancement: a narrative review

British Journal of Sports Medicine, 2016
Recent reports from the World Anti-Doping Agency (WADA) indicate an alarming prevalence in the use of meldonium among elite athletes. Therefore, in January 2016, meldonium was added to WADA's prohibited list after being monitored since 2015. Meldonium has been shown to have beneficial effects in cardiovascular, neurological and metabolic diseases due ...
Wolfgang, Schobersberger, Tobias, Dünnwald, Günther, Gmeiner, Cornelia, Blank   +3 more
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UPLC‐MS/MS method for bioequivalence study of oral drugs of meldonium

Biomedical Chromatography, 2011
ABSTRACTA rapid and simple method based on ultra‐performance liquid chromatography on a hydrophilic interaction chromatography column with tandem mass‐selective detection (UPLC‐MS/MS) to determine meldonium in human plasma was developed. The calibration curve acquired in the range of 10–6000 ng/mL had quadratic form.
Yuriy V, Pidpruzhnykov, Valerii E, Sabko, Volodymyr V, Iurchenko, Igor A, Zupanets   +3 more
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Testing for Meldonium, a Doping Agent, in Human Hair

Drug Testing and Analysis
ABSTRACTMeldonium has been developed in the 70s in Latvia and is currently used in a limited number of countries for heart‐related diseases, such as heart attack, failure, or angina pectoris. Due to its metabolic properties (decrease of lactate production, increase of glycogen use, and protective action again oxidative stress), meldonium has been ...
Pascal Kintz, Jean‐Claude Alvarez, Laurie Gheddar   +2 more
openaire   +1 more source