Results 181 to 190 of about 11,509 (217)
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Über Melittin, XI. Drei Melittine im Bienengift
Justus Liebigs Annalen der Chemie, 1972AbstractAus Bienengift wird durch Gelfiltration und Chromatographie über einen Kationenaustauscher (CM‐Cellulose) Melittin (einheitlicher Gipfel) eluiert. Mittels Elektrophorese auf Cellogel (Cellulose‐acetat) wird das chromatographierte Melittin in mindestens 3 Komponenten aufgespalten. Die Methode ist einfach und gut reproduzierbar.
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The interaction of melittin with troponin C
Archives of Biochemistry and Biophysics, 1987Melittin has been found to interact with troponin C with high affinity in the presence of Ca2+. The association constant approaches in magnitude that for melittin and calmodulin. The interaction results in a shift to lower wavelengths of the emission band of Trp-19 of melittin and in an increased shielding of Trp-19 from quenching.
R F, Steiner, L, Norris
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Interaction of melittin with lipid membranes
Biochimica Et Biophysica Acta - Biomembranes, 1994Interaction of melittin with lipid membranes was studied systematically with respect to its adsorption onto membranes, its effect on membrane leakage and fusion, and micellization at various melittin/lipid ratios. It was found that melittin has a strong affinity for adsorption onto lipid membranes.
Shinpei Ohki, Klaus Arnold, Emil Marcus
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Topology of the calmodulin-melittin complex.
Journal of molecular biology, 1998The topology of the Ca2+-calmodulin-melittin ternary complex has been investigated by a combined strategy which integrates limited proteolysis and cross-linking experiments with mass spectrometric methodologies. The rationale behind the methods is that the interface regions of two interacting proteins are accessible to the solvent in the isolated ...
Scaloni A +6 more
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Membrane matrix disruption by melittin
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1972Abstract Electron spin resonance spectroscopy was used to examine the interaction of the lytic polypeptide, melittin, with model membrane systems in order to determine the physical basis for its alterations of membrane properties. Sonically dispersed egg lecithin (phosphatidylcholine), phosphatidylserine, extracted Escherichia coli phospholipids, and
J C, Williams, R M, Bell
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Molecular parameters in melittin immunogenicity
Journal of Peptide Science, 1997Based on immunogenicity studies, two T-cell epitopes in melittin were found to be functional in guinea pigs, one being centrally located, the other one residing in the C-terminal chain. In Balb/c mice only the central epitope was found to be active. A human T-cell clone was found by T-cell proliferation studies to employ strictly the C-terminal chain ...
Curcio-Vonlanthen V +4 more
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Characterization of Melittin Effects in Synaptosomes
Neurochemical Research, 1997The effects of melittin at increasing concentrations on: [3H]GABA release from mouse brain synaptosomes; on the radioactivity released from [3H]arachidonic acid labeled synaptosomal membranes; on synaptosomes ultrastructure and on the leakage of the cytoplasmic marker, lactate-dehydrogenase (LDH) was investigated.
L, González +3 more
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Mechanism of the conformational transition of melittin
Biochemistry, 1992It is known that, while melittin at micromolar concentrations is unfolded under conditions of low ionic strength at neutral pH, it adopts a tetrameric alpha-helical structure under conditions of high ionic strength, at alkaline pH, or at high peptide concentrations.
Y, Goto, Y, Hagihara
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Melittin interactions with adenylate cyclase
Biochimica et Biophysica Acta (BBA) - General Subjects, 1977Melittin, a basic polypeptide from bee venom, inhibits basal and thyrotropin-stimulated adenylate cyclase of beef thyroid membranes with a Ki approximately 10 micron. Although this property resides in the basic C-terminal and not the N-terminal portion of the molecule, inhibition is due primarily to its detergent-like nature rather than charge effects.
G H, Cook, J, Wolff
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Melittin: from honeybees to superbugs
Applied Microbiology and Biotechnology, 2019The emergence of antibiotic-resistant bacteria, dubbed superbugs, together with relative stagnation in developing efficient antibiotics has led to enormous health and economic problems, necessitating the need for discovering and developing novel antimicrobial agents. In this respect, animal venoms represent a rich repertoire of pharmacologically active
Hamed Memariani +5 more
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