Results 81 to 90 of about 35,440 (290)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Influence of High-Temperature Treatment of Melt on the Composition and Structure of Aluminum Alloy

open access: yesArchives of Foundry Engineering, 2017
The aim of the current study was to examine the structure of an alloy treated at various temperatures up to 2,000-2,100 °C. Among research techniques for studying alloy structure there were the electron and optical microstructure, X-ray structure, and ...
Grachev V. A., Turakhodjaev N. D.
doaj   +1 more source

Large Silicic Eruptions, Episodic Recharge, and the Transcrustal Magmatic System

open access: yesGeochemistry, Geophysics, Geosystems, 2020
Large silicic eruptions result from rapid evacuation of large, upper crustal reservoirs of silicic magmas. These silicic magmas are thought to be replenished by melt extracted from underlying crystal‐rich source mushes, but the timescales and mechanisms ...
Boda Liu, Cin‐Ty Lee
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Magnetic properties and magnetocaloric effects of rare-earth based high-entropy amorphous microwires

open access: yesJournal of Materials Research and Technology
The development of efficient and environmentally friendly solid-state refrigeration materials is a key issue in magnetic refrigeration technology. Rare-earth based high-entropy alloys with good magnetocaloric effect have been recently recognized as good ...
Shijie Wei   +4 more
doaj   +1 more source

Properties of microfibrillar cellulose filled thermoplastic natural rubber: Morphology, mechanical properties, and melt flow index

open access: yesMajalah Kulit, Karet, dan Plastik, 2020
Microfibrillar cellulose (MFC) was derived from local pineapple leaf fiber (PALF) and employed as filler in thermoplastic natural rubber (TPNR), that was a blend of natural rubber (NR) and polypropylene (PP).
Ihda Novia Indrajati   +2 more
doaj   +1 more source

Slip‐rate‐dependent melt extraction at oceanic transform faults

open access: yesGeochemistry, Geophysics, Geosystems, 2015
AbstractCrustal thickness differences between oceanic transform faults and associated mid‐ocean ridges may be explained by melt migration and extraction processes. Slow‐slipping transform faults exhibit more positive gravity anomalies than the adjacent spreading centers, indicating relative thin crust in the transform domain, whereas at intermediate ...
Hailong Bai, Laurent G. J. Montési
openaire   +1 more source

Analytical study of space processing of immiscible materials for superconductors and electrical contacts [PDF]

open access: yes
The results of a study conducted to determine the role space processing or materials research in space plays in the superconductor and electrical contact industries are presented.
Abbott, W. H.   +3 more
core   +1 more source

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