Results 91 to 100 of about 128,718 (308)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A General Model for the Permeability of Magma Mush

Geochemistry, Geophysics, Geosystems
Percolation through magma mush is a key transport mechanism for melts in the crust and is influenced by the permeability of the crystal framework. Existing models for mush permeability do not account for the range of microstructures that can evolve as ...
Eloïse Bretagne, Fabian B. Wadsworth, Jérémie Vasseur, Katherine E. Schofield, Madeleine C. S. Humphreys, Katherine J. Dobson   +5 more
doaj   +1 more source

A Magnetron Plasma Arc Fusion Identification Study Based on GPCC-CNN-SVM Multi-Source Signal Fusion

Sensors
Plasma arc welding (PAW) is commonly employed for welding medium and thick plates due to its capability of single-side welding and double-side forming. Ensuring welding quality necessitates real-time precise identification of the melting state.
Yeming Zou, Dongqian Wang, Yuanyuan Qu, Hao Liu, Aiting Jia, Bo Hong   +5 more
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

An analogue model of melt segregation and accumulation processes in the Earth’s crust [PDF]

Estonian Journal of Earth Sciences, 2007
An analogue experiment was carried out to model melt segregation from the solid rock matrix and its subsequent transport. Carbon dioxide gas and sand were used as analogue materials of crustal partial melt and host rock, respectively.
Soesoo, Alvar, Urtson, Kristjan
doaj  

A Positive Feedback Between Crustal Thickness and Melt Extraction for the Origin of the Martian Dichotomy. [PDF]

J Geophys Res Planets, 2022
Bonnet Gibet V, Michaut C, Wieczorek M, Lognonné P.   +3 more
europepmc   +1 more source

Abundance and Partitioning of OH in a High-pressure Magmatic System: Megacrysts from the Monastery Kimberlite, South Africa [PDF]

, 2004
Concentrations of OH, and major and trace elements were determined in a suite of mantle-derived megacrysts that represent the crystallization products of a kimberlite-like magma at ~5 GPa and ~1400–1100°C.
Bell, David R., Moore, Rory O., Rossman, George R.   +2 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source