Results 41 to 50 of about 1,222,916 (246)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Debris cover and surface melt at a temperate maritime alpine glacier: Franz Josef Glacier, New Zealand [PDF]

, 2012
Melt rates on glaciers are strongly influenced by the presence of supraglacial debris, which can either enhance or reduce ablation relative to bare ice.
Brook, Martin S., Winkler, S, Hagg, W, Hagg, Wilfried, Winkler, Stefan, Brook, M. S.   +5 more
core   +1 more source

Physics-guided spatiotemporal approach for melt pool size prediction in laser powder bed fusion

Virtual and Physical Prototyping
This study first proposes a physics-guided spatiotemporal graph. The melt pool temporal feature nodes and spatial feature nodes are extracted from melt pool images based on spatiotemporal correlations. These feature points are treated as graph nodes, and
Yangkun Mao, Xin Lin, Haihong Zhu, Kunpeng Zhu   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Understanding magma genesis through analysis of melt inclusions: application of innovative micro-sampling techniques [PDF]

, 2007
Melt entrapped as inclusions in early-formed phenocrysts provide geochemists with an exceptional opportunity to study sample material from the earliest stages in the formation of a suite of lavas.
Harlou, Rikke
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Modelling the controls on melt generation during continental extension and breakup

, 2008
Rifting is the process that leads to the formation of oceans. Rifting is the break up ofcontinents, leading to the formation of new oceanic floor between the two continentalplates.
Armitage, John J.
core   +1 more source

Continuous change monitoring of supraglacial lakes during melt and non-melt seasons with multi-source satellite imagery and deep learning

International Journal of Applied Earth Observations and Geoinformation
The surface melting of ice sheets is gradually intensifying with rising global temperatures. Supraglacial lakes (SGLs), an essential component of the ice-surface hydrological system, are significant for the ice sheet mass balance. SGLs have been shown to
Dongyu Zhu, Chunxia Zhou, Xiaoli Chen, Jiani Ouyang, Ce Zhang   +4 more
doaj   +1 more source

Geodynamic Models of Melt Generation and Extraction at Mid-Ocean Ridges [PDF]

Oceanography, 2012
It is widely accepted that plate divergence at mid-ocean ridges drives mantle flow, mantle melting, and the formation of new oceanic crust. However, many of the details of this process remain obscure because of the inaccessibility of the mantle to direct
Patricia M. Gregg, Laura B. Hebert, Laurent G.J. Montési, Richard F. Katz   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source