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Alternative Granulation Technique: Melt Granulation
Drug Development and Industrial Pharmacy, 1996AbstractA melt granulation process has been investigated (1, 2) which efficiently agglomerates pharmaceutical powders for use in both immediate- and sustained-release solid dosage forms. The process utilizes materials that are effective as granulating fluids when they are in the molten state.
Alan Royce +3 more
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Preparation of Essential Oils Loaded Granule by Melt Granulation
Drug Development and Industrial Pharmacy, 1994AbstractA comparative study on three granulation methods; melt granulation, fluidized bed granulation and wet granulation was performed to fabricate an essential oils loaded granule. The granule properties such as particle size distribution and the loading efficiency of anethole from fennel and cinnamaldehyde from cinnamon showed that the melt ...
Kenji Ukita, Toshio Murakami
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MELT GRANULATION: AN ALTERNATIVE TO TRADITIONAL GRANULATION TECHNIQUES
INDIAN DRUGS, 2013Melt granulation is a size enlargement process in which the addition of a binder that melts or softens at relatively low temperatures (about 60o C) is used to achieve agglomeration of solid particles in the formulation. The process utilizes materials that are effective as granulating agents when they are in the softened or molten state.
U.S Desai +3 more
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Twin-screw melt granulation: Current progress and challenges
International Journal of Pharmaceutics, 2020Twin-screw melt granulation (TSMG) is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. TSMG has rapidly gained interest over recent years in the pharmaceutical industry. Since it is an inherently continuous process with controlled temperature and shear history, TSMG produces products with ...
Nada Kittikunakorn +2 more
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Melting a granulated chemically activated batch
Glass and Ceramics, 1986This paper investigates the results of preparative chemical activation and comminution of glass feedstocks prior to their melting in a furnace and also assesses the effects of this treatment on the productivity and energy efficiency of the furnace.
N. A. Mamina +3 more
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Preparation and evaluation of granules with pH-dependent release by melt granulation
International Journal of Pharmaceutics, 2012This study had two objectives: (1) to prepare, by melt granulation in a high-shear mixer, granules containing acetaminophen (APAP) as a model drug and aminoalkyl methacrylate copolymer E (AMCE) as a pH-sensitive polymer that readily dissolves at pH values lower than 5, and (2) to investigate the effects of AMCE loading (5-15%) on granule properties and
Kai, Shiino +3 more
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Fast-melting tablets based on highly plastic granules
Journal of Controlled Release, 2005Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder.
Yourong, Fu +2 more
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Characteristics of piroxicam granules prepared by fluidized bed hot melt granulation
Advanced Powder Technology, 2018Abstract The aim of this study was to investigate the granulation of piroxicam by fluidized bed hot melt method using polyethylene glycol 4000 as the hydrophilic carrier and spray dried lactose as the fluidizing substrate. The effects of the spray nozzle air flow rate, axial position of the spray nozzle and load of fluidizing substrate on granules ...
Marília M.S. Vieira +2 more
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Dissolution enhancement of carbamazepine using twin-screw melt granulation
European Journal of Pharmaceutics and Biopharmaceutics, 2020The current study explored the twin-screw melt granulation (TSMG) as a potential technology for the water solubility enhancement of biopharmaceutical classification system (BCS) class II drugs. As a model drug, carbamazepine (CBZ) was formulated with three different polymers as melt granules produced in a co-rotating twin-screw granulator. Polyethylene
Kristina E, Steffens, Karl G, Wagner
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The study of salt melt granulation process
AIP Conference Proceedings, 2017The numerical simulation method was used to determine the distribution of the cooling air velocities in the granulator volume, the change in the layer temperature during the granulation process, and also the study of the efficiency of heat transfer from the salt melt layer to air.The numerical simulation method was used to determine the distribution of
Ksenia V. Kuznetsova +3 more
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