Results 71 to 80 of about 12,198,711 (338)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The energetics of melting fertile heterogeneities within the depleted mantle [PDF]

, 2011
To explore the consequences of mantle heterogeneity for primary melt production, we develop a mathematical model of energy conservation for an upwelling, melting body of recycled oceanic crust embedded in the depleted upper mantle.
Katz, R. F., Rudge, John F., Richard F. Katz, John F. Rudge   +3 more
core   +2 more sources

Research progress in low-temperature solders for electronic packaging

Cailiao gongcheng
The combination of multiple temperature gradients in interconnect solders is key to achieving high-density chip integration. Low-temperature solder alloys are the premise for implementing low-temperature processes and the guarantee for high reliability ...
LI Fangliang, GAN Guisheng, DOU Junfeng, XIE Daochun, ZHU Junxiong, GENG Mingli, HAN Jun, YANG Donghua, PAN Hao, XIA Daquan, XU Xiangtao   +10 more
doaj   +1 more source

Investigating the highest melting temperature materials: A laser melting study of the TaC-HfC system

Scientific Reports, 2016
TaC, HfC and their solid solutions are promising candidate materials for thermal protection structures in hypersonic vehicles because of their very high melting temperatures (>4000 K) among other properties.
Omar Cedillos-Barraza, D. Manara, K. Boboridis, Tyson Watkins, S. Grasso, D. Jayaseelan, R. Konings, M. Reece, William E. Lee   +8 more
semanticscholar   +1 more source

Melting Behavior of Nylon 6 Ultra Micro Fibers Having Different Diameters [PDF]

, 2003
P(論文)Melting behavior of Nylon 6 ultra micro fibers and micro fibers with 0.4～21.0μm diameters has been inbestigated. Two peaks were observed for the melting of the ultra micro fibers.
12082, MARUI, MASAKI, 12081, 12073, 12084, 12083, 12075, 12074, 12077, 12076, 丸井, 正樹, YAMAMOTO, NAOKO, 牛腸, ヒロミ, KOMIYAMA, JIRO, 12080, ヤマモト, ナオコ, ゴチョウ, ヒロミ, 12079, 12078, 山本, 直子, 小見山, 二郎, コミヤマ, ジロウ, GOCHO, HIROMI, マルイ, マサキ   +23 more
core  

Evaluation of spa-typing of methicillin-resistant Staphylococcus aureus using high-resolution melting analysis [PDF]

, 2015
OBJECTIVE: spa-typing of methicillin-resistant Staphylococcus aureus (MRSA) has been widely used in clinical diagnostics and epidemiological studies. We aimed to evaluate high-resolution melting (HRM) as a rapid and cost effective method, to replace DNA ...
Gunnar Sandstrom, Waleed Mazi, Vartul Sangal, Yu, J, Saeed, Amir, Sandstrom, Gunnar, Sangal, Vartul, Sangal, V, Sandstom, Gunnar, Amir Saeed, Mazi, W,, Jun Yu, Sandstrom, G, Saeed, A,, Mazi, Waleed, Yu, Jun   +15 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion

Pharmaceutics, 2023
Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous processing technology, used to design custom products by co-processing drugs together with functional excipients. In this context, the residence time and processing temperature during extrusion are critical process parameters for ensuring the highest product qualities,
Judith Winck, Tobias Gottschalk, Markus Thommes   +2 more
openaire   +4 more sources