Results 181 to 190 of about 6,428,720 (262)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Perspectives on the impact of regulatory measures on national COVID-19 vaccination programs: a qualitative study from six EU member states. [PDF]

J Pharm Policy Pract
van Vliet ED, Buhl C, Jacobsen R, Andersen A, Almarsdóttir AB, Dermiki-Gkana F, Oikonomou C, Deligianni E, Kontogiorgis C, Kos M, Čebron Lipovec N, Ribeiro-Vaz I, Silva AM, Ferreira P, Poplavska E, Abtahi S, Hegger I, Leonardo Alves T.   +17 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Current status of radiologist staffing, education and training in the 27 EU Member States. [PDF]

Insights Imaging
Brady AP, Paulo G, Brkljacic B, Loewe C, Szucsich M, Hierath M, European Society of Radiology.   +6 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Voluntary information and price sharing database - a scoping review of the pricing and procurement landscape across eight Commonwealth Member States. [PDF]

J Pharm Policy Pract
Kebirungi B, Ocran P, Kamere N, Mabote LK, Osi N, Joshi-von Heyden M, Gilmour E, Mghamba J, Robinson L, Babar ZU, Rosado H, Rutter V.   +11 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Estimated unit costs of anaemia interventions for women of reproductive age in 193 UN member states: a costing study. [PDF]

Lancet Haematol
Oliver VL, Wang Y, Leung S, Blythe R, Glover-Wright C, Holloway-Brown J, Bode M, Pasricha SR, Carvalho N.   +8 more
europepmc   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Integration of family planning and nutrition programmes in 64 WHO member states of Africa, Eastern Mediterranean and South-East Asia regions: findings from a survey of Ministry of Health officials. [PDF]

BMJ Glob Health
Shah IH, Ali M, Habib NA, Baloch AA, Ouedraogo L, Aderoba A, Gholbzouri K, Upadhyay MT, Jarathilake A, Fawzi W, Partap U.   +10 more
europepmc   +1 more source