The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
New Labour Laws in Old Member States : Trade Union Responses to European Enlargement
, 2016 On 1 May 2004, eight post-communist states in Central and Eastern Europe joined the European Union. On 1 January 2007, Romania and Bulgaria became the ninth and tenth Eastern European States to accede to the EU.
Zahn, Rebecca
core
Mental health prevention in Poland and selected European Union member states: a comparative analysis of systemic interventions. [PDF]
Front Public HealthWeber D +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Is health financing converging in the European Union? Nonlinear dynamics and policy implications for non-euro area member states. [PDF]
Front Public HealthDritsaki M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Some impacts of the EU accession on the new member states’ agriculture [PDF]
The main aim of the paper is to analyse the impact of the EU accession on the New Member States’ agriculture with special regard to production, employment, farmers’ income and intra-EU trade in agricultural goods on the basis of the latest statistical ...
Judit KISS
core
Live bovine animal export dynamics and structural heterogeneity across European member states, 2014-2024: A cluster -based analysis. [PDF]
Vet Anim SciSkujina E, Pilvere I.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
The Meaning of Leadership in Medical Education in the Pan American Health Organization Member States: A Stakeholder Analysis and Interviews. [PDF]
Int J Public HealthRodríguez-Feria P +7 more
europepmc +1 more source