Results 151 to 160 of about 671,733 (267)

Seasonal Occurrence of African Swine Fever in Wild Boar and Domestic Pigs in EU Member States. [PDF]

Viruses, 2023
Rogoll L, Güttner AK, Schulz K, Bergmann H, Staubach C, Conraths FJ, Sauter-Louis C.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Assessing European Union member states' progress toward antimicrobial sales reduction targets under the European Green Deal: A comparative policy and performance analysis. [PDF]

Vet World
Muska A, Pilvere I, Upite I, Muska K, Nipers A.   +4 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Physical activity promotion and health-enhancing physical activity education policy in EU healthcare: a cross-sectional survey of 27 member states. [PDF]

BMJ Open
Leese C, Whiting S, Mendes R.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

MAPPING current decision-making pathways and reimbursement processes for high-risk medical devices in EU/EEA member states and the UK: a scoping review. [PDF]

Int J Technol Assess Health Care
Alshaikh RA, Walsh KA, El-Komy F, Spillane S, Carrigan M, Larkin L, Harrington P, O'Neill M, Teljeur C, Ryan M, O'Driscoll CM.   +10 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Public Health Decision-Maker Perspective on Joint Clinical Assessments in Central European EU Member States. [PDF]

J Mark Access Health Policy
Merész G, Dankó D, Molnár MP.
europepmc   +1 more source