Results 131 to 140 of about 5,362,504 (373)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

Thermodynamic competition between membrane protein oligomeric states

open access: yes, 2016
Self-assembly of protein monomers into distinct membrane protein oligomers provides a general mechanism for diversity in the molecular architectures, and resulting biological functions, of membrane proteins.
Haselwandter, Christoph A.   +1 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

Membrane-mediated interactions between arc-shaped particles strongly depend on membrane curvature [PDF]

open access: yesarXiv
Besides direct molecular interactions, proteins and nanoparticles embedded in or adsorbed to membranes experience indirect interactions that are mediated by the membranes. These membrane-mediated interactions arise from the membrane curvature induced by the particles and can lead to assemblies of particles that generate highly curved spherical or ...
arxiv  

Quantum measurement backaction from a BEC coupled to a mechanical oscillator

open access: yes, 2011
We study theoretically the dynamics of a a hybrid optomechanical system consisting of a macroscopic mechanical membrane magnetically coupled to a spinor Bose-Einstein condensate via a nanomagnet attached at the membrane center.
K. C. Schwab   +6 more
core   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Membrane boundary condition [PDF]

open access: yesarXiv, 2000
Using a microscopic phase-space model of the membrane system, the boundary condition at a membrane is derived. According to the condition, the substance flow across the membrane is proportional to the difference of the substance concentrations at the opposite membrane surfaces.
arxiv  

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