Results 51 to 60 of about 3,266,442 (267)

The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

Communications Biology, 2023
In arterial myocytes, the canonical function of voltage-gated CaV1.2 and KV2.1 channels is to induce myocyte contraction and relaxation through their responses to membrane depolarization, respectively.
Collin Matsumoto, Samantha C. O’Dwyer, Declan Manning, Gonzalo Hernandez-Hernandez, Paula Rhana, Zhihui Fong, Daisuke Sato, Colleen E. Clancy, Nicholas C. Vierra, James S. Trimmer, L. Fernando Santana   +10 more
doaj   +1 more source

Membranes on an Orbifold

Physical Review Letters, 2008
We harvest clues to aid with the interpretation of the recently discovered N=8 supersymmetric Chern-Simons theory with SO(4) gauge symmetry. The theory is argued to describe two membranes moving in the orbifold R8/Z2. At level k=1 and k=2, the classical moduli space M coincides with the infra-red moduli space of SO(4) and SO(5) super Yang-Mills theory ...
Lambert, N, Tong, D
openaire   +4 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Reconstructed Polyamide Nanolayers via Two‐Stage Interfacial Polymerization Engineering for Precise Ion Sieving

Advanced Science
Efficient lithium extraction from brines remains challenging due to the comparable hydrated radii of Li+ and Mg2+ and the extreme ionic strength of the feed solutions. In this work, a reconstructed polyamide (PA) nanofiltration membrane was developed via
Shuzhen Zhao, Liheng Dai, Feidong Yang, Bowen Li, Pengfei Zhang, Yanyan Liu, Mengyang Hu, Kecheng Guan, Ryosuke Takagi, Hideto Matsuyama   +9 more
doaj   +1 more source

Techno-economic process optimization for a range of membrane performances: What provides real value for point-source carbon capture?

Carbon Capture Science & Technology
Membranes provide a unique opportunity for heavy industry decarbonization and a real solution requires optimal system design. We use a superstructure process model to minimize capital and operational expenses for post-combustion carbon capture systems ...
Joshua C. Watson, Kenneth J. Pennisi, Christine Parrish, Sudip Majumdar   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Kinetic selectivity in metal-organic framework chemical sensors

Nature Communications
Selective detection of specific volatile organic compounds (VOCs) is crucial for health, safety, and environmental applications, but current sensors suffer from poor selectivity and struggle to measure specific VOCs in the presence of interfering ...
Aleksander Matavž, Margot F. K. Verstreken, Leen Boullart, Max L. Tietze, Masaya Sugihara, Lars Heinke, Rob Ameloot   +6 more
doaj   +1 more source

Modelling of Ion Transport in Electromembrane Systems: Impacts of Membrane Bulk and Surface Heterogeneity

Applied Sciences, 2018
Artificial charged membranes, similar to the biological membranes, are self-assembled nanostructured materials constructed from macromolecules.
Victor Nikonenko, Andrey Nebavsky, Semyon Mareev, Anna Kovalenko, Mahamet Urtenov, Gerald Pourcelly   +5 more
doaj   +1 more source