Results 141 to 150 of about 69,381 (252)

Membrane curvature governs the distribution of Piezo1 in live cells. [PDF]

Nat Commun, 2022
Yang S, Miao X, Arnold S, Li B, Ly AT, Wang H, Wang M, Guo X, Pathak MM, Zhao W, Cox CD, Shi Z.   +11 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Engineering a membrane-binding protein to trimerize and induce high membrane curvature. [PDF]

Biophys J, 2023
Hakami Zanjani AA, Mularski A, Busk Heitmann AS, Dias C, Møller ME, Maeda K, Nylandsted J, Simonsen AC, Khandelia H.   +8 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Investigating the effects of membrane curvature inducing proteins on lipid droplets in Saccharomyces cerevisiae. [PDF]

Mol Biol Rep
Niemelä LRK, Tunn I, Frey AD.
europepmc   +1 more source

Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery. [PDF]

Sci Adv, 2022
Jensen LE, Rao S, Schuschnig M, Cada AK, Martens S, Hummer G, Hurley JH.   +6 more
europepmc   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

A model for membrane curvature generation by caveolin discs driven by differential contact interaction. [PDF]

Nat Commun
Barnoy A, Ariotti N, Parton RG, Kozlov MM.   +3 more
europepmc   +1 more source

Nanoscale membrane curvature sorts lipid phases and alters lipid diffusion. [PDF]

Biophys J, 2023
Woodward X, Javanainen M, Fábián B, Kelly CV.   +3 more
europepmc   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source