Results 141 to 150 of about 1,587,373 (355)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Optimization of Hydrolysis Conditions and Antibacterial Activity of Hydrolysate from Shrimp Processing By-products

Shipin gongye ke-ji
Objective: In order to investigate the use of by-products from aquatic product processing in the preparation of antibacterial hydrolysates and their antibacterial effects, in this study, the specific spoilage organisms of Penaeus vannamei (PV-SSOs) were ...
Luo GU, Ru SONG
doaj   +1 more source

Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells1, [PDF]

, 2008
Alberto Finamore, Mara Massimi, Laura Conti Devirgiliis, Elena Mengheri   +3 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Antibacterial Activity and Mode of Action of β-caryophyllene on Bacillus cereus [PDF]

Polish Journal of Microbiology, 2020
CHEW-LI MOO, SHUN-KAI YANG, MOHD-AZURAIDI OSMAN, MOHD HAFIS YUSWAN, JIUN-YAN LOH, WEI-MENG LIM, SWEE-HUA-ERIN LIM, KOK-SONG LAI   +7 more
doaj   +1 more source

Relationship between antimicrobial peptides-induced cell membrane damage and bactericidal activity. [PDF]

Biophys J, 2023
Islam MZ, Hossain F, Ali MH, Yamazaki M.
europepmc   +1 more source

INVESTIGATION ON DAMAGE TO LARGE MEMBRANE ROOF DURING HEAVY SNOW IN FEBRUARY 2014 AND CONSIDERATION FOR ARTIFICIAL BREAKAGE OF ROOF MATERIAL

, 2016
Ken rsquo ichi KAWAGUCHI, Shota NONAKA
openalex   +1 more source

Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

, 2021
Dennis J. Doorduijn, Dani A. C. Heesterbeek, Maartje Ruyken, Carla J. C. de Haas, Daphne A. C. Stapels, Piet C. Aerts, Suzan H. M. Rooijakkers, Bart W. Bardoel   +7 more
openalex   +2 more sources

Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes [PDF]

, 2022
Andrey V. Kozlov, Johannes Grillari
openalex   +1 more source