Results 301 to 310 of about 1,587,373 (355)
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Selenite-lnduced Damage to Lens Membranes
Experimental Eye Research, 1994The present study focuses on three aspects of membrane damage to explain selenite-induced loss of ion homeostasis: membrane transport processes, i.e. cation pump; biosynthesis of membrane proteins and membrane permeability. Cation pump activity, assessed by both 86Rb uptake and Na-K-ATPase activity in the epithelium, was observed to decline gradually ...
K, Hightower, J, McCready
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Nav Channels in Damaged Membranes
2016Sick excitable cells (ie, Nav channel-expressing cells injured by trauma, ischemia, inflammatory, and other conditions) typically exhibit "acquired sodium channelopathies" which, we argue, reflect bleb-damaged membranes rendering their Nav channels "leaky." The situation is excitotoxic because untreated Nav leak exacerbates bleb damage.
C E, Morris, B, Joos
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Membrane Damage Efficiency of Phenothiazinium Photosensitizers
Photochemistry and Photobiology, 2014AbstractStructure–activity relationships have been widely reported for porphyrin and phthalocyanine photosensitizers, but not for phenothiazinium derivatives. Here, four phenothiazinium salts (methylene blue, toluidine blue O, 1,9‐dimethyl methylene blue and the pentacyclic derivative DO15) were used to investigate how the ability to damage membranes ...
Isabel O L, Bacellar +5 more
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Membrane damage in acute brain trauma
The Italian Journal of Neurological Sciences, 1989Among a number of biochemical disturbances occurring in the acute phase of brain insults, the destruction of membrane phospholipids and its consequences on the function of membrane-bound proteins is likely to be one of the most important. In the cryogenic type of injury which is classically considered as a relevant animal model of brain contusive ...
F, Cohadon +3 more
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MEMBRANE DAMAGE IN UV‐IRRADIATED LENSES
Photochemistry and Photobiology, 1994Abstract The purpose of this study was to investigate three possible causes of membrane damage following UV irradiation: photooxidation of membrane thiol (SH) groups, peroxidation of membrane lipids and inhibited synthesis of membrane proteins. Thiol loss was not observed.
K R, Hightower +2 more
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Dealing with damage: Plasma membrane repair mechanisms
Biochimie, 2014Eukaryotic cells have developed repair mechanisms, which allow them to reseal their membrane in order to prevent the efflux of cytoplasmic constituents and the uncontrolled influx of calcium. After injury, the Ca(2+)-concentration gradient fulfils a dual function: it provides guidance cues for the repair machinery and directly activates the molecules ...
Annette, Draeger +4 more
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Cryobiology, 1978
Abstract Sarcoplasmic reticulum membrane vesicles (SRV), isolated from the abdominal muscle of Maine lobsters, were put through a freeze-thaw cycle in order to study membrane freezing damage on a molecular basis, The major membrane protein in SRV is a (Ca 2+ − Mg 2+ ) ATPase capable of accumulating Ca 2+ with the concomitant hydrolysis of ATP ...
J R, Lepock +3 more
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Abstract Sarcoplasmic reticulum membrane vesicles (SRV), isolated from the abdominal muscle of Maine lobsters, were put through a freeze-thaw cycle in order to study membrane freezing damage on a molecular basis, The major membrane protein in SRV is a (Ca 2+ − Mg 2+ ) ATPase capable of accumulating Ca 2+ with the concomitant hydrolysis of ATP ...
J R, Lepock +3 more
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Atomic Insights into Amyloid-Induced Membrane Damage
ACS Chemical Neuroscience, 2022Amphipathic peptides can cause biological membranes to leak either by dissolving their lipid content via a detergent-like mechanism or by forming pores on the membrane surface. These modes of membrane damage have been related to the toxicity of amyloid peptides and to the activity of antimicrobial peptides.
Yanxing Yang +5 more
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Functional Consequences of Oxidative Membrane Damage
Journal of Membrane Biology, 2005The interaction of reactive oxygen species with biological membranes is known to produce a great variety of different functional modifications. Part of these modifications may be classified as direct effects. They are due to direct interaction of the reactive species with the molecular machinery under study with a subsequent chemical and functional ...
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Peroxide-induced membrane damage in human erythrocytes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1985Erythrocytes exposed to H2O2 or t-butyl hydroperoxide (tBHP) exhibited lipid peroxidation and increased passive cation permeability. In the case of tBHP a virtually complete inhibition of both processes was caused by butylated hydroxytoluene (BHT), whereas pretreatment of the cells with CO increased both lipid peroxidation and K+ leakage.
J, van der Zee +2 more
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