Results 81 to 90 of about 1,587,373 (355)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A Role for Secondary Metabolites in Desiccation Tolerance in Lichens

open access: yesMicrobiology Research
In lichens, secondary metabolites have been shown to protect against biotic stresses such as pathogen attacks and grazing, and abiotic stresses such as ultraviolet (UV) and high photosynthetically active radiation (PAR).
Nqobile Truelove Ndhlovu   +2 more
doaj   +1 more source

Inoculation of plant-growth-promoting rhizobacteria in Myracrodruon urundeuva Allemão supports in tolerance to drought stress

open access: yesJournal of Plant Interactions, 2018
This study evaluated the influence of Azospirillum lipoferum on the growth of Myracroduon urundeuva (Anacardiaceae) plants under drought stress, by means of biometric, physical–chemical and biochemical parameters. The association of A. lipoferum with the
Douglas Moreira de Oliveira   +5 more
doaj   +1 more source

A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice. [PDF]

open access: yes, 2001
Dystrophin-deficient muscles experience large reductions in expression of nitric oxide synthase (NOS), which suggests that NO deficiency may influence the dystrophic pathology.
Spencer, MJ, Tidball, JG, Wehling, M
core  

Punicalagin Damages the Membrane of Salmonella Typhimurium

open access: yesJournal of Food Protection, 2020
Salmonella, a bacterial foodborne pathogen, can contaminate meat, milk, and vegetables. While appropriate measures are available to control Salmonella, the inhibitory phytochemicals from plants are gaining increased attention. Punicalagin, a natural antimicrobial, is one of the main active tannins isolated from Punica granatum L.
Guanghui Li   +3 more
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Studies on the Inhibition Mechanism of Linalyl Alcohol against the Spoilage Microorganism Brochothrix thermosphacta

open access: yesFoods
The aim of this study was to investigate the bacterial inhibitory ability and mechanism of action of linalyl alcohol against B. thermosphacta. Linalyl alcohol causes the leakage of intracellular material by disrupting the cell wall and exposing the ...
Longteng Wang   +3 more
doaj   +1 more source

Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes

open access: yesRedox Report, 2021
Objective The aim of this study was to investigate how modifications at the periphery of the porphyrin ring affect the anticancer activity of Mn porphyrins (MnPs)-based SOD mimics. Methods Six compounds: MnTE-2-PyP with a short ethyl chain on the pyridyl
Bader Hasan   +3 more
doaj   +1 more source

Membrane charge and lipid packing determine polymyxin-induced membrane damage

open access: yesCommunications Biology, 2019
AbstractWith the advent of polymyxin B (PmB) resistance in bacteria, the mechanisms for mcr-1 resistance are of crucial importance in the design of novel therapeutics. The mcr-1 phenotype is known to decrease membrane charge and increase membrane packing by modification of the bacterial outer membrane.
Adree Khondker   +6 more
openaire   +2 more sources

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