Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions [PDF]
Viruses, 2015 The envelopes of coronaviruses (CoVs) contain primarily three proteins; the two major glycoproteins spike (S) and membrane (M), and envelope (E), a non-glycosylated protein.
Makoto Ujike, Fumihiro Taguchi
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Influenza hemagglutinin and neuraminidase membrane glycoproteins. [PDF]
J Biol Chem, 2010 Considerable progress has been made toward understanding the structural basis of the interaction of the two major surface glycoproteins of influenza A virus with their common ligand/substrate: carbohydrate chains terminating in sialic acid. The specificity of virus attachment to target cells is mediated by hemagglutinin, which acquires characteristic ...
Gamblin SJ, Skehel JJ.
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Antibody binding reports spatial heterogeneities in cell membrane organization [PDF]
Nature Communications, 2023 The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane.
Daniel P. Arnold +2 more
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Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export. [PDF]
Elife, 2016 LAMP1 and LAMP2 proteins are highly abundant, ubiquitous, mammalian proteins that line the lysosome limiting membrane, and protect it from lysosomal hydrolase action. LAMP2 deficiency causes Danon’s disease, an X-linked hypertrophic cardiomyopathy. LAMP2
Li J, Pfeffer SR.
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Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions. [PDF]
J Proteome Res, 2015 Biomarkers capable of detecting and targeting epithelial ovarian cancer cells for diagnostics and therapeutics would be extremely valuable. Ovarian cancer is the deadliest reproductive malignancy among women in the U.S., killing over 14 000 women each ...
Allam H +6 more
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Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]
PLoS ONE, 2012 Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
Margarete E Swadzba +4 more
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Herpesvirus glycoproteins undergo multiple antigenic changes before membrane fusion. [PDF]
PLoS ONE, 2012 Herpesvirus entry is a complicated process involving multiple virion glycoproteins and culminating in membrane fusion. Glycoprotein conformation changes are likely to play key roles.
Daniel L Glauser +2 more
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Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib. [PDF]
Journal of Clinical Investigation, 1985 Experiments were performed to determine whether platelets contain a membrane skeleton. Platelets were labeled by a sodium periodate/sodium [3H]borohydride method and lysed with Triton X-100. Much of the filamentous actin could be sedimented at low g forces (15,600 g, 4 min), but some of the actin filaments required high-speed centrifugation for their ...
J. Fox
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Crosslinking of the Glycoproteins in Human Erythrocyte Membranes [PDF]
Proceedings of the National Academy of Sciences, 1974 The glycoproteins of human erythrocyte membranes were crosslinked with dimethyl adipimidate dihydrochloride. On sodium dodecyl sulfate-polyacrylamide gel electrophoregrams of the crosslinked solubilized membranes, at least three new glycoprotein complexes appeared in addition to the normal glycoprotein species. One of the new glycoprotein complexes was
Tae H. Ji
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Viruses, 2021 Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) are prototypical alphaherpesviruses that are characterized by their unique properties to infect trigeminal and dorsal root ganglionic neurons, respectively, and establish life-long latent infections.
Nithya Jambunathan +5 more
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