Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions [PDF]
Viruses, 2015 The envelopes of coronaviruses (CoVs) contain primarily three proteins; the two major glycoproteins spike (S) and membrane (M), and envelope (E), a non-glycosylated protein.
Makoto Ujike, Fumihiro Taguchi
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TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins [PDF]
Autophagy ReportsSelective autophagy of the endoplasmic reticulum (ER-phagy/reticulophagy) is essential for organelle homeostasis and host defense, yet how ER quality control (ERQC) pathways distinguish viral glycoproteins from misfolded host proteins remains poorly ...
Jim Maurice Camilleri +5 more
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Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner [PDF]
eLifeVarious types of glycoproteins have been suggested to inhibit viral infection of cells via steric repulsion. However, it is difficult to evaluate such physical actions genetically, simply because they are nonspecific and can be caused by any molecule ...
Yoshihisa Kaizuka, Rika Machida
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Does Altered Membrane Glycosylation Contribute to Neurodevelopmental Dysfunction in Autism Spectrum Disorder? [PDF]
MembranesNeuronal development relies on cell-surface glycoconjugates that function as complex bioinformational codes. Recently, altered glycosylation has emerged as a central mechanistic theme in the pathophysiology of autism spectrum disorder (ASD).
Vinicius J. S. Osterne +5 more
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Viruses, 2021 Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) are prototypical alphaherpesviruses that are characterized by their unique properties to infect trigeminal and dorsal root ganglionic neurons, respectively, and establish life-long latent infections.
Nithya Jambunathan +5 more
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Glycan structures contain information for the spatial arrangement of glycoproteins in the plasma membrane. [PDF]
PLoS ONE, 2013 Glycoconjugates at the cell surface are crucial for cells to communicate with each other and the extracellular microenvironment. While it is generally accepted that glycans are vectorial biopolymers, their information content is unclear.
M Kristen Hall +4 more
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Tamoxifen-resistant breast cancer cells exhibit reactivity with Wisteria floribunda agglutinin.
PLoS ONE, 2022 Glycosylation is one of the most important post-translational modifications of cell surface proteins involved in the proliferation, metastasis and treatment resistance of cancer cells.
May Thinzar Hlaing +11 more
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PLoS Biology, 2023 Enveloped viruses encode specialised glycoproteins that mediate fusion of viral and host membranes. Discovery and understanding of the molecular mechanisms of fusion have been achieved through structural analyses of glycoproteins from many different ...
Michael R Oliver +5 more
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Communications Biology, 2021 Reiding et al. performed conventional proteomics as well as glycoproteomics on protein extracts from lysates of pooled neutrophils obtained from ten healthy donors.
Karli R. Reiding +4 more
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Antibody binding reports spatial heterogeneities in cell membrane organization
Nature Communications, 2023 The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane.
Daniel P. Arnold +2 more
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