Results 171 to 180 of about 1,256,081 (297)

Glycoproteins as components of cellular membranes

Progress in Biophysics and Molecular Biology, 1973
openaire   +2 more sources

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Adapting in-cell ELISA to investigate the localization of hepatitis C virus envelope glycoproteins. [PDF]

Microbiol Spectr
Dimitriadis S, Edmans M, Frumento N, Hong Xiang N, Bailey J, Cox A, Klenerman P, Barnes E, Zurbia-Flores GM.   +8 more
europepmc   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Syncytium-forming HSV-1 in cancer gene therapy: From molecular mechanisms to clinical translation. [PDF]

Virulence
Zhao X, Zhang H, Xu S, Mei L, Feng Z, Wang D, Huang W, Shen Y.   +7 more
europepmc   +1 more source

Terminal Galactosylation and Sialylation Switching on Membrane Glycoproteins upon TNF-Alpha-Induced Insulin Resistance in Adipocytes. [PDF]

Mol Cell Proteomics, 2016
Parker BL, Thaysen-Andersen M, Fazakerley DJ, Holliday M, Packer NH, James DE.   +5 more
europepmc   +1 more source

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation. [PDF]

J Clin Med
Li Y, Yang P, Yuan M, Zhu X, Mao S, Yang Y, Yao M, Chen F, Zhou Y, Bao J, Xu C, Li Y.   +11 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Glycoprotein-induced phase separation drives unconventional secretion of galectin-3. [PDF]

Nat Commun
Zhao Z, He Z, Gu H, Zhou A, Wang Y, Liang Z, Geng J, Xu X, Wang M, Li C, Fan Y, Cheng H, Sun L, Mayo KH, Raz A, Tai G, Zhou Y.   +16 more
europepmc   +1 more source