Results 61 to 70 of about 2,350,953 (316)

Unveiling the metabolic fate of monosaccharides in cell membranes with glycomic and glycoproteomic analyses. [PDF]

, 2019
Cell membrane protein glycosylation is dependent on the metabolic state of the cell as well as exogenous nutrients available. Although the metabolism and interconversion of monosaccharides have been well-studied, their incorporation into cell surface ...
Cheng, Zhi, Lebrilla, Carlito B, Li, Qiongyu, Park, Dayoung, Wong, Maurice, Xu, Gege   +5 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Transient Transfection-based Fusion Assay for Viral Proteins

Bio-Protocol, 2017
Membrane fusion is vital for entry of enveloped viruses into host cells as well as for direct viral cell-to-cell spread. To understand the fusion mechanism in more detail, we use an infection free system whereby fusion can be induced by a minimal set of ...
Melina Vallbracht, Christina Schröter, Barbara Klupp, Thomas Mettenleiter   +3 more
doaj   +1 more source

Critical role of the fusion protein cytoplasmic tail sequence in parainfluenza virus assembly. [PDF]

PLoS ONE, 2013
Interactions between viral glycoproteins, matrix protein and nucleocapsid sustain assembly of parainfluenza viruses at the plasma membrane. Although the protein interactions required for virion formation are considered to be highly specific, virions ...
Raychel Stone, Toru Takimoto
doaj   +1 more source

Glucocorticoid-regulated localization of cell surface glycoproteins in rat hepatoma cells is mediated within the Golgi complex. [PDF]

, 1988
Glucocorticoid hormones regulate the post-translational maturation and sorting of cell surface and extracellular mouse mammary tumor virus (MMTV) glycoproteins in M1.54 cells, a stably infected rat hepatoma cell line.
APONTE, Gregory W., Bravo, D, Firestone, G, Haffar, O, Hess, R, John, N   +5 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Challenging the Existing Model of the Hexameric HIV-1 Gag Lattice and MA Shell Superstructure: Implications for Viral Entry

Viruses, 2021
Despite type 1 human immunodeficiency virus (HIV-1) being discovered in the early 1980s, significant knowledge gaps remain in our understanding of the superstructure of the HIV-1 matrix (MA) shell.
Joy Ramielle L. Santos, Weijie Sun, Tarana A. Mangukia, Eduardo Reyes-Serratos, Marcelo Marcet-Palacios   +4 more
doaj   +1 more source

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. [PDF]

, 2018
Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface.
Haigh, Nathan E, Lebrilla, Carlito B, Liu, Mingqi, Maverakis, Emanual, Park, Diane Dayoung, Phoomak, Chatchai, Wong, Maurice, Wongkham, Sopit, Xu, Gege, Yang, Pengyuan   +9 more
core  

Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro [PDF]

, 2004
Background: Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on ...
Annett Streu, Beer AE, Crosignani PG, Dagmar-Ulrike Richter, Heiner Müller, Ioannis Mylonas, Jeschke U, Julkunen M, Julkunen M, Julkunen M, Klaus Friese, Kliman HJ, Loh TT, Mandler RN, Martinovic S, Mylonas I, Okamoto N, Seki H, Shanker YG, Siiteri PK, Starreveld JS, Udo Jeschke, Vanderpuye OA, Volker Briese, Zelewski L   +24 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source