Results 81 to 90 of about 222,944 (309)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

A Comprehensive Review of Our Current Understanding of Red Blood Cell (RBC) Glycoproteins

Membranes, 2017
Human red blood cells (RBC), which are the cells most commonly used in the study of biological membranes, have some glycoproteins in their cell membrane. These membrane proteins are band 3 and glycophorins A–D, and some substoichiometric glycoproteins (e.
Takahiko Aoki
doaj   +1 more source

Fusion of secretory vesicles isolated from rat liver [PDF]

, 1978
Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
A. Amsterdam, A. Ichikawa, A. Lernmark, A.R. Poole, B. Hellman, B. Rose, C. Miller, C. Schudt, C. Schudt, C.M. Croge, D. Banerjee, D. Branton, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, E.K. Matthews, E.L. Pesanti, F. Malaisse-Lagae, G. Dahl, G. Dahl, G. Dahl, G. Poste, G. Virgilis De, G.M. Grodsky, G.R. Lawford, Gerhard Dahl, H. Schachter, J. Stadler, J.H. Ehrenreich, J.J.M. Bergeron, J.L. Mongar, J.S. Hong, L. Keay, L. Winquist, L.E. Hokin, M. Gratzl, M. Gratzl, M. Gratzl, M. Gratzl, M. Raiteri, M. Redman, M. Reporter, M.G. Farquar, Manfred Gratzl, N.A. Thorn, O. Stein, O.H. Lowry, P. Röhlich, P. Seeman, Q.F. Ahkong, R. Dipolo, R. Ekholm, R. Llinás, R. Miledi, R.C. Baker, R.D. Andrew, R.M. Case, R.P. Rubin, S.J. Burwen, T. Kanno, T. Maeda, T.Ch. Normann, W. Berger, W. Breisblatt, W. Breisblatt, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, Y. Marchand Le   +75 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics

Viruses, 2012
The Paramyxoviridae genus Henipavirus is presently represented by the type species Hendra and Nipah viruses which are both recently emerged zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in ...
Dimitar B. Nikolov, Christopher C. Broder, Deborah L. Steffen, Kai Xu   +3 more
doaj   +1 more source

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

Protein signatures of molecular pathways in non-small cell lung carcinoma (NSCLC): comparison of glycoproteomics and global proteomics

Clinical Proteomics, 2017
Background Non-small cell lung carcinoma (NSCLC) remains the leading cause of cancer deaths in the United States. More than half of NSCLC patients have clinical presentations with locally advanced or metastatic disease at the time of diagnosis. The large-
Shuang Yang, Lijun Chen, Daniel W. Chan, Qing Kay Li, Hui Zhang   +4 more
doaj   +1 more source

Assembly and architecture of the EBV B cell entry triggering complex. [PDF]

, 2014
Epstein-Barr Virus (EBV) is an enveloped double-stranded DNA virus of the gammaherpesvirinae sub-family that predominantly infects humans through epithelial cells and B cells.
Chen, Jia, Hu, Yao Xiong, Jardetzky, Theodore S, Jiang, Jiansen, Jiang, Wei, Longnecker, Richard, Mellins, Elizabeth D, Möhl, Britta S, Rowe, Cynthia L, Sathiyamoorthy, Karthik, Zhou, Z Hong   +10 more
core   +4 more sources

The Coronavirus Membrane Glycoprotein [PDF]

, 1995
Coronaviruses have a simple protein composition. While there is some variation among different members, a basic set of four protein species universally occurs: the nucleocapsid protein (N), the spike protein (S), a small membrane protein (SM), and the membrane glycoprotein (M). Some coronaviruses have an additional membrane glycoprotein (HE).
openaire   +1 more source