Results 61 to 70 of about 222,944 (309)

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]

, 2016
Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I, Kontoravdi, C, Polizzi, K   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Congenital abnormalities of platelet membrane glycoproteins

Journal of Associated Medical Sciences, 2010
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Preeyanat Vongchan
doaj  

Implication des peptides de fusion des glycoprotéines de fusion virales de classe I dans la fusion membranaire [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2007
The implication of fusion peptides of class I viral fusion glycoproteins in the membrane fusion. Viral infection involves fusion between the viral envelope and the target cell plasmic membrane.
Brasseur R., Charloteaux B., Lins L., Lorin A.   +3 more
doaj  

N-glycoproteome analysis of the secretome of human metastatic hepatocellular carcinoma cell lines combining hydrazide chemistry, HILIC enrichment and mass spectrometry. [PDF]

PLoS ONE, 2013
Cancer cell metastasis is a major cause of cancer death. Unfortunately, the underlying molecular mechanisms remain unknown, which results in the lack of efficient diagnosis, therapy and prevention approaches. Nevertheless, the dysregulation of the cancer
Xianyu Li, Jing Jiang, Xinyuan Zhao, Jifeng Wang, Huanhuan Han, Yan Zhao, Bo Peng, Rugang Zhong, Wantao Ying, Xiaohong Qian   +9 more
doaj   +1 more source

Identification of N-Glycoproteins of Knee Cartilage from Adult Osteoarthritis and Kashin-Beck Disease Based on Quantitative Glycoproteomics, Compared with Normal Control Cartilage

Cells, 2022
Glycoproteins are involved in the development of many diseases, while the type and content of N-glycoproteins in the cartilage of osteoarthritis (OA) and Kashin–Beck disease (KBD) are still unclear.
Jing Han, Huan Deng, Yizhen Lyu, Xiang Xiao, Yan Zhao, Jiaxin Liu, Ziwei Guo, Xuan Liu, Lichun Qiao, Hang Gao, Mikko Juhani Lammi   +10 more
doaj   +1 more source

Lewis X antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-Type lectin [PDF]

, 2007
Lewis x (Lex, CD15), also known as SSEA-1 (stage specific embryonic antigen-1), is a trisaccharide with the structure Galβ(1–4)Fucα(1–3)GlcNAc, which is expressed on glycoconjugates in human polymorphonuclear granulocytes and various tumors such as colon
A Hittelet, AM Roon van, C Ballaré, D Vestweber, DS Johnston, E Spooncer, EA Jaffé, ED Ball, EG Rizzatti, F Sánchez-Madrid, HC Gooi, HD Soule, IHN Wong, J Kitayama, J Mitoma, J Mordoh, J Mordoh, J-W Liao, JF Harris, JI Yamashita, JL Magnani, José Mordoh, JP Buyon, K Drbal, KL Allendoerfer, KM Skubitz, KM Skubitz, KP Gisbergen van, Kurt Drickamer, L Lucka, M Albrechtsen, M Capurro, M Capurro, M-L Majuri, Mariana Isabel Capurro, María Marcela Barrio, María Teresa Elola, Maureen E. Taylor, MK Robinson, ML Phillips, MM Burdick, N Kawamura, O Ohana-Malka, Peter J. Coombs, PJ Coombs, R Giavazzi, R Kannagi, S D´Costa, S Hakomori, SC Stocks, T Bild, TB Geijtenbeek   +51 more
core   +1 more source

Membrane Glycoproteins of Enveloped Viruses

, 1978
This chapter focuses on the recent information of the glycoprotein components of enveloped viruses and points out specific findings on viral envelopes. Although enveloped viruses of different major groups vary in size and shape, as well as in the molecular weight of their structural polypeptides, there are general similarities in the types of ...
Compans, Richard W., Kemp, Maurice C.
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture. [PDF]

, 1980
We have shown that macrophages in culture degrade the glycoproteins and amorphous elastin of insoluble extracellular matrices. Ultrastructural observation of the macrophage-matrix interaction revealed that connective tissue macromolecules were ...
Bainton, DF, Jones, PA, Werb, Z
core