Results 81 to 90 of about 2,327,252 (364)

Sorting of Lysosomal Membrane Glycoproteins lamp-1 and lamp-2 into Vesicles Distinct from Mannose 6-Phosphate Receptor/γ-Adaptin Vesicles at the trans-Golgi Network*

Journal of Biological Chemistry, 1998
Newly synthesized lysosomal membrane glycoproteins lamp-1 and lamp-2 are primarily sorted at thetrans-Golgi network (TGN) by recognition of a tyrosine-based signal sequence in their cytoplasmic tails. It is presently unclear how this signal is recognized
K. Karlsson, S. Carlsson
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Desialylation of lysosomal membrane glycoproteins by Trypanosoma cruzi: a role for the surface neuraminidase in facilitating parasite entry into the host cell cytoplasm

Journal of Experimental Medicine, 1992
Trypanosoma cruzi enters host cells via formation of an acidic vacuole which is subsequently disrupted, allowing the parasite access to the cytoplasm.
B F Hall, P. Webster, A K Ma, K A Joiner, N. Andrews   +4 more
semanticscholar   +1 more source

Lewis X antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-Type lectin [PDF]

, 2007
Lewis x (Lex, CD15), also known as SSEA-1 (stage specific embryonic antigen-1), is a trisaccharide with the structure Galβ(1–4)Fucα(1–3)GlcNAc, which is expressed on glycoconjugates in human polymorphonuclear granulocytes and various tumors such as colon
A Hittelet, AM Roon van, C Ballaré, D Vestweber, DS Johnston, E Spooncer, EA Jaffé, ED Ball, EG Rizzatti, F Sánchez-Madrid, HC Gooi, HD Soule, IHN Wong, J Kitayama, J Mitoma, J Mordoh, J Mordoh, J-W Liao, JF Harris, JI Yamashita, JL Magnani, José Mordoh, JP Buyon, K Drbal, KL Allendoerfer, KM Skubitz, KM Skubitz, KP Gisbergen van, Kurt Drickamer, L Lucka, M Albrechtsen, M Capurro, M Capurro, M-L Majuri, Mariana Isabel Capurro, María Marcela Barrio, María Teresa Elola, Maureen E. Taylor, MK Robinson, ML Phillips, MM Burdick, N Kawamura, O Ohana-Malka, Peter J. Coombs, PJ Coombs, R Giavazzi, R Kannagi, S D´Costa, S Hakomori, SC Stocks, T Bild, TB Geijtenbeek   +51 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Membrane integration and intracellular transport of the coronavirus glycoprotein E1, a class III membrane glycoprotein.

Journal of Biological Chemistry, 1988
The E1-glycoprotein (Mr = 26,014; 228 amino acids) of mouse hepatitis virus A59 is a class III membrane glycoprotein which has been used in this study as a model system in the study of membrane integration and protein transport. The protein lacks an NH2-terminal cleavable signal sequence and spans the viral membrane three times.
Matthias M. Falk, Heiner Niemann, Teruko Tamura, T Mayer   +3 more
openaire   +3 more sources

Purification of Membrane-Bound Glycoprotein [PDF]

Thrombosis and Haemostasis, 1977
Glycocalicin (Mr 150,000) is a component of the platelet glycocalyx and is released in soluble form on platelet homogenization. Glycocalicin appears to play a central role in platelet aggregation induced by thrombin and ristocetin. In addition, the membrane fraction can be resolved into four glycoprotein bands by one-dimensional gel SDS electrophoresis
G.A. Jamieson, I.M. Hasitz, T. Okumura
openaire   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Laminin–a glycoprotein from basement membranes.

Journal of Biological Chemistry, 1979
We have isolated a large noncollagenous glycoprotein, laminin, from a mouse tumor that produces basement membrane. The protein consists of at least two polypeptide chains (Mr = 220,000 and Mr = 440,000) joined to each other by disulfide bonds. Laminin and type IV collagen are major constituents of the tumor.
Rupert Timpl, Stephen I. Rennard, Jean-Michel Foidart, George R. Martin, H Rohde, Pamela Gehron Robey   +5 more
openaire   +3 more sources