Results 171 to 180 of about 678,998 (299)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Familial mutations modulate α-synuclein interactions with key neuronal membrane lipids. [PDF]

FEBS J
Ali A, Matveyenka M, Kurouski D.
europepmc   +1 more source

Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid. [PDF]

Antioxidants (Basel), 2023
Gładysz AK, Stępniak J, Karbownik-Lewińska M.   +2 more
europepmc   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Ornithine lipids and other acyloxyacyl amino lipids: the coming-of-age story of a group of non-canonical membrane lipids. [PDF]

Appl Microbiol Biotechnol
Moyano-Palazuelo D, Vences-Guzmán MÁ, Sohlenkamp C.   +2 more
europepmc   +1 more source

Membrane lipids and maximum lifespan in clownfish. [PDF]

Fish Physiol Biochem, 2022
Almaida-Pagan PF, Lucas-Sanchez A, Martinez-Nicolas A, Terzibasi E, de Lama MAR, Cellerino A, Mendiola P, de Costa J.   +7 more
europepmc   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Membrane Lipids and Osmolytes Rearrangements Under Cell Wall Stress in <i>Aspergillus niger</i>. [PDF]

Int J Mol Sci
Ianutsevich EA, Danilova OA, Saharova SA, Tereshina VM.   +3 more
europepmc   +1 more source

Effect of Drought Stress on Degradation and Remodeling of Membrane Lipids in Nostoc flagelliforme. [PDF]

Foods, 2022
Wang M, Zhu Q, Li X, Hu J, Song F, Liang W, Ma X, Wang L, Liang W.   +8 more
europepmc   +1 more source

BACH, a Bayesian Optimization Protocol for Accurate Coarse‐Grained Parameterization of Organic Liquids

Advanced Functional Materials, EarlyView.
We present a fully automated Bayesian optimization (BO) protocol for the parameterization of nonbonded interactions in coarse‐grain CG force fields (BACH). Using experimental thermophysical data, we apply the protocol to a broad range of liquids, spanning linear, branched, and unsaturated hydrocarbons, esters, triglycerides, and water.
Janak Prabhu, Akhil Pratap Singh, Pablo Campomanes, Stefano Vanni   +3 more
wiley   +1 more source