Results 291 to 300 of about 3,142,426 (357)

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

open access: yesAdvanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen   +7 more
wiley   +1 more source

Advancing from MOFs and COFs to Functional Macroscopic Porous Constructs

open access: yesAdvanced Materials, EarlyView.
This review study investigates the recent progress and methodologies for manufacturing metal–organic framework (MOF) or covalent–organic framework (COF)‐based 3D structured macroscopic porous constructs with high structural integrity, providing the possibility to control their porosity across dimensions.
Seyyed Alireza Hashemi   +8 more
wiley   +1 more source

Computational Modeling of Reticular Materials: The Past, the Present, and the Future

open access: yesAdvanced Materials, EarlyView.
Reticular materials are advanced materials with applications in emerging technologies. A thorough understanding of material properties at operating conditions is critical to accelerate the deployment at an industrial scale. Herein, the status of computational modeling of reticular materials is reviewed, supplemented with topical examples highlighting ...
Wim Temmerman   +3 more
wiley   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

open access: yesAdvanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle   +9 more
wiley   +1 more source

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

open access: yesAdvanced Materials, EarlyView.
Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi   +8 more
wiley   +1 more source

Vascularized and Perfusable Human Heart‐on‐a‐Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery

open access: yesAdvanced Materials, EarlyView.
This novel 3D human ischemic heart‐on‐a‐chip, with perfusable vasculature directly interfaced with myocardial tissue, replicates key aspects of ischemic heart injury. It also demonstrates the targeted delivery and therapeutic efficacy of cardiac homing peptide‐conjugated liposomes, validating the platform for drug and nanomedicine screening in ...
Junyoung Kim   +14 more
wiley   +1 more source

Membranes and bioactive lipids

Biochimie, 2013
International ...
Girard-Egrot, Agnès, Lagarde, Michel
openaire   +5 more sources

Membrane Lipid Nanodomains

Chemical Reviews, 2018
Lipid membranes can spontaneously organize their components into domains of different sizes and properties. The organization of membrane lipids into nanodomains might potentially play a role in vital functions of cells and organisms. Model membranes represent attractive systems to study lipid nanodomains, which cannot be directly addressed in living ...
Marek Cebecauer   +6 more
openaire   +4 more sources

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