Results 41 to 50 of about 17,685 (286)

Drop-Casted Self-Assembled Topological Insulator Membrane as an Effective Saturable Absorber for Ultrafast Laser Photonics

IEEE Photonics Journal, 2015
Through employing a cost-effective solvothermal method, ultrathin topological insulator (TI) bismuth telluride (Bi2Te3) nanosheets with uniform hexagonal nanostructures had been synthesized.
Qingkai Wang, Yu Chen, Guobao Jiang, Lili Miao, Chujun Zhao, Xiquan Fu, Shuangchun Wen, Han Zhang   +7 more
doaj   +1 more source

Biophysical basis of the sound analogue membrane potential that underlies coincidence detection in the barn owl

Frontiers in Computational Neuroscience, 2013
Interaural time difference (ITD), or the difference in timing of a sound wave arriving at the two ears, is a fundamental cue for sound localization. A wide variety of animals have specialized neural circuits dedicated to the computation of ITDs.
Go eAshida, Kazuo eFunabiki, Kazuo eFunabiki, Catherine E. Carr   +3 more
doaj   +1 more source

Measurements of membrane patch capacitance using a software-based lock-in system

Pflügers Archiv - European Journal of Physiology, 2007
On-cell patch-clamp capacitance measurements can resolve the fusion of individual vesicles to a membrane patch and the accompanying dilation of the fusion pore. So far, these measurements have used a patch-clamp amplifier in combination with a hardware lock-in amplifier.
Neef, Andreas, Heinemann, Christian, Moser, Tobias   +2 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Brain-State-Dependent Modulation of Neuronal Firing and Membrane Potential Dynamics in the Somatosensory Thalamus during Natural Sleep

Cell Reports, 2019
Summary: The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM).
Nadia Urbain, Nicolas Fourcaud-Trocmé, Samuel Laheux, Paul A. Salin, Luc J. Gentet   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

A shell finite element formulation to analyze highly deformable rubber-like materials

Latin American Journal of Solids and Structures
: In this paper, a shell finite element formulation to analyze highly deformable shell structures composed of homogeneous rubber-like materials is presented. The element is a triangular shell of any-order with seven nodal parameters. The shell kinematics
J. P. Pascon, H. B. Coda
doaj   +1 more source

Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly

Scientific Reports, 2020
In neuronal exocytosis, SNARE assembly into a stable four-helix bundle drives membrane fusion. Previous studies have revealed that the SM protein Munc18-1 plays a critical role for precise SNARE assembly with the help of Munc13-1, but the underlying ...
Sanghwa Lee, Jonghyeok Shin, Younghun Jung, Heyjin Son, Jaeil Shin, Cherlhyun Jeong, Dae-Hyuk Kweon, Yeon-Kyun Shin   +7 more
doaj   +1 more source

Handbook of Establishing and Maintaining Oxygen‐Free Atmospheres

Advanced Engineering Materials, EarlyView.
This study presents a practical framework for creating oxygen‐free atmospheres at ambient pressure using silane‐doped inert gases. The results show that ultra‐low oxygen levels and strongly reduced water content can be achieved through controlled silane dosing, drying systems, and sensor monitoring.
Sascha Jan Zimmermann, René Gustus, Lienhard Wegewitz, Wolfgang Maus‐Friedrichs   +3 more
wiley   +1 more source