Results 231 to 240 of about 2,952,338 (294)
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A Highly Efficient Tumor‐Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism
Advances in Materials, 2019Efficient tumor targeting has been a great challenge in the clinic for a very long time. The traditional targeting methods based on enhanced permeability and retention (EPR) effects show only an ≈5% targeting rate.
Zhendong Lei +11 more
semanticscholar +1 more source
Measurement of membrane permeability and the mitochondrial permeability transition
2020The mitochondrial permeability transition (PT) is an increase in the inner membrane permeability caused by the opening of a Ca2+-activated high-conductance channel, the so-called PT pore (PTP) or mitochondrial megachannel (MMC). Recent data indicate that F-ATP synthase contributes substantially to the generation of the PTP, yet this hypothesis is the ...
Carraro M., Bernardi P.
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Permeability of the Synovial Membrane to Proteins
Acta Rheumatologica Scandinavica, 1963SummaryThe normal synovial membrane has been shown to be only slightly permeable to proteins, especially certain glycoproteins. After filtration of serum through a hyaluronic acid gel in vitro a protein profile similar to that of normal synovial fluid is obtained.
Erik Nettelbladt +2 more
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Langmuir, 2018
Cellular membranes are exposed to extreme conditions during the processing steps involved in cryopreservation (and freeze-drying) of cells. The first processing step involves adding protective agents.
W. Wolkers +5 more
semanticscholar +1 more source
Cellular membranes are exposed to extreme conditions during the processing steps involved in cryopreservation (and freeze-drying) of cells. The first processing step involves adding protective agents.
W. Wolkers +5 more
semanticscholar +1 more source
Measurement of Membrane Permeability and the Permeability Transition of Mitochondria
2007Publisher Summary This chapter focuses on the experimental procedures designed to measure apoptosis-associated mitochondrial membrane permeabilization, either in intact cells or in isolated mitochondria. Following a variety of death signals, mitochondria show early alterations in their function that at least in some instances may be explained by the ...
Guido Kroemer +3 more
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Nature, 1968
Cellular Aspects of Membrane Permeability By E. Schoffeniels. (International Series of Monographs in Pure and Applied Biology. Division: Modern Trends in Physiological Sciences, Vol. 28.) Pp. xiii + 266. (Pergamon: Oxford, London and New York, 1967.) 100s.; $15.
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Cellular Aspects of Membrane Permeability By E. Schoffeniels. (International Series of Monographs in Pure and Applied Biology. Division: Modern Trends in Physiological Sciences, Vol. 28.) Pp. xiii + 266. (Pergamon: Oxford, London and New York, 1967.) 100s.; $15.
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ChemPhysChem, 2017
Cyclic peptides have regained interest as potential inhibitors of challenging targets but have often a low bioavailability. The natural product cyclosporine A (CsA) is the textbook exception.
Jagna Witek +6 more
semanticscholar +1 more source
Cyclic peptides have regained interest as potential inhibitors of challenging targets but have often a low bioavailability. The natural product cyclosporine A (CsA) is the textbook exception.
Jagna Witek +6 more
semanticscholar +1 more source
Improving the Membrane Permeability of 5-Fluorouracil via Cocrystallization
, 2016Pharmaceutical cocrystallization is proposed as a new method to enhance membrane permeability of a BCS class III model drug, 5-fluorouracil (5FU). Three cocrystals of 5FU, 5FU/3-hydroxybenzoic acid (1), 5FU/4-aminobenzoic acid (2), and 5FU/cinnamic acid (
Xia-Lin Dai +3 more
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2016
Synthetic and natural cyclic peptides provide a testing ground for studying membrane permeability in nontraditional drug scaffolds. Cyclic peptomers, which incorporate peptide and N-alkylglycine (peptoid) residues, combine the stereochemical and ...
A. Furukawa +5 more
semanticscholar +1 more source
Synthetic and natural cyclic peptides provide a testing ground for studying membrane permeability in nontraditional drug scaffolds. Cyclic peptomers, which incorporate peptide and N-alkylglycine (peptoid) residues, combine the stereochemical and ...
A. Furukawa +5 more
semanticscholar +1 more source
The engineering of membrane-permeable peptides
Analytical Biochemistry, 2005Reversible lipid attachment was investigated as a means to deliver small peptides into cells. Two labile straight chain alkyl motifs were developed: a cysteine dodecane disulfide (Cdd) building block and a tyrosine- or serine-myristate ester. Both moieties are cleaved on cell internalization and are compatible with Fmoc solid phase peptide synthesis. A
Barbara Imperiali, Christina N. Carrigan
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