Results 221 to 230 of about 474,230 (265)
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Protein unfolding by the mitochondrial membrane potential
Nature Structural Biology, 2002Mitochondria can unfold importing precursor proteins by unraveling them from their N-termini. However, how this unraveling is induced is not known. Two candidates for the unfolding activity are the electrical potential across the inner mitochondrial membrane and mitochondrial Hsp70 in the matrix.
Shihai, Huang +2 more
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Membrane Potential of Mitochondrial Measured with Microelectrodes
Science, 1977The membrane potentials of giant mitochondria from cuprizone-fed mice were found to be independent of metabolic state. Experiments are described in which the presence of the microelectrodes in the inner mitochondrial space, and the metabolic viability of the impaled mitochonidra, are validated.
B L, Maloff, S P, Scordilis, H, Tedeschi
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The plasma membrane and mitochondrial membrane potentials of Plasmodium yoelii
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19881. The plasma membrane potential and the mitochondrial membrane potential of P. yoellii was examined by fluorescence microscopy using rhodamine 123 and by transmembrane distribution of tetraphenylphosphonium. 2. The mitochondrion of P. yoelii, free of gametocyte stage, maintained a high negative inside membrane potential. 3.
A, Izumo, K, Tanabe, M, Kato
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Assessment of mitochondrial membrane potential as an indicator of cytotoxicity
Fundamental and Applied Toxicology, 1991Mechanistically based short-term in vitro tests to evaluate the relative cytotoxicity of of chemicals will complement in vitro genotoxicity testing during the initial phases of toxicity evaluation as well as provide information on the cellular site of action for chemicals found to be toxic in animals.
C A, Rahn, D W, Bombick, D J, Doolittle
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The effect of atovaquone on the mitochondrial membrane potential of Babesia gibsoni
Experimental Parasitology, 2022Atovaquone (ATV) has a growth inhibitory effect against Babesia gibsoni. The target site is considered mitochondria, as in the case of Plasmodium spp.; ATV would collapse the mitochondrial membrane potential. B. gibsoni has also reported that single nucleotide polymorphisms in cytochrome b of mitochondria are involved in ATV susceptibility.
Aiko Iguchi +6 more
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Probing mitochondrial membrane potential
C&EN Global Enterprise, 2020Mitochondrial membrane potential, an indicator of mitochondrial function, is perturbed in many diseases , including cancer and neurodegenerative diseases, but difficult to measure noninvasively.
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Regulation of the Cardiac Mitochondrial Membrane Potential by Retinoids
The Journal of Pharmacology and Experimental Therapeutics, 2003Cardiomyocytes suffering irreversible damage under oxidative stress during ischemia activate their suicide program. Mitochondria play a key role in this process, while they themselves are subject to regulation by a number of signaling pathways. We demonstrate here that retinoids influence mitochondrial function in cardiomyocytes.
Irina, Korichneva +2 more
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Visualization of mitochondrial membrane potential in mammalian cells
2020Assessment of the mitochondrial membrane potential (Δψ) in living cells, although not trivial, can be used to estimate mitochondrial bioenergetic state. For this purpose, fluorescent lipophilic cations are broadly applied. These cations enter cells and accumulate primarily in the mitochondrial matrix in a Δψ-dependent manner.
Esteras, N. +4 more
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The direction of polarity of the mitochondrial trans-membrane potential
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1969Abstract The concentration of various anions in the sucrose impermeable space of ratliver mitochondria relative to the applied concentration can be used to calculate an equilibrium potential if one supposes that the anion distribution is passive. Values so calculated for anions of different net charge are about 30 mV, with the interior positive.
E J, Harris, B C, Pressman
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Measurement of Mitochondrial Membrane Potential and Proton Leak
2009The major component of mitochondrial electrochemical potential gradient of protons is the mitochondrial membrane potential (DeltaPsi), and hence it is a suitable parameter for assessment of mitochondrial function. Dissipation of the mitochondrial membrane potential causes uncoupling of the electron transport through the respiratory chain and the ...
Serviddio G., Sastre J.
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