Results 71 to 80 of about 704,164 (306)
Inherent mitochondrial activity influences specification of the germ line in pluripotent stem cells
Heliyon, 2020 Herein we investigated whether inherent differences in mitochondrial activity in mouse pluripotent cells could be used to identify populations with an intrinsic ability to differentiate into primordial germ cells (PGCs).
Alisha M. Bothun, Dori C. Woods
doaj +1 more source
Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore [PDF]
, 2001 The mitochondrial permeability transition is a widely studied, but poorly understood, phenomenon in mitochondrial bioenergetics. It has been recognised that this phenomenon is related to the opening of a protein pore in the inner mitochondrial membrane ...
Coxito, Pedro M. +5 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Saudi Pharmaceutical JournalThe mitochondria are responsible for the production of cellular ATP, the regulation of cytosolic calcium levels, and the organization of numerous apoptotic proteins through the release of cofactors necessary for the activation of caspases.
Adel Alghamdi
doaj +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2016 This study evaluated the plasma membrane integrity, acrosomal membrane integrity, and mitochondrial membrane potential of Nelore bull sperm from early puberty to early sexual maturity and their associations with sperm motility and vigor, the mass ...
L.S.L.S. Reis +3 more
doaj +1 more source
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. [PDF]
, 2019 Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Alnemri, Emad S. +5 more
core +3 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Biogenesis of mitochondrial porin [PDF]
, 1990 We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins.
A. Grossmann +74 more
core +1 more source
Mitochondrial membrane potential disruption pattern in human sperm [PDF]
Human Reproduction, 2009 Loss of mitochondrial membrane potential (DeltaPsi(m)) in spermatozoa is correlated with high levels of reactive oxygen species in semen, abnormal spermiogram parameters, and low success rates of IVF. In somatic cells, the loss of DeltaPsi(m) is primarily associated with several mechanisms of cell death, mainly the activation of caspases. The impact of
Jaime A, Espinoza +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source