Results 71 to 80 of about 474,230 (265)

Simultaneous imaging of cell and mitochondrial membrane potentials

Biophysical Journal, 1989
The distribution of charged membrane-permeable molecular probes between intracellular organelles, the cytoplasm, and the outside medium is governed by the relative membrane electrical potentials of these regions through coupled equilibria described by the Nernst equation. A series of highly fluorescent cationic dyes of low membrane binding and toxicity
Farkas, D.L., Wei, M.D., Febbroriello, P., Carson, J.H., Loew, L.M.   +4 more
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology

Redox Biology, 2014
A recent study revealed a mechanism of delaying aging in yeast by a natural compound which specifically impacts mitochondrial redox processes. In this mechanism, exogenously added lithocholic bile acid enters yeast cells, accumulates mainly in the inner ...
Michelle T. Burstein, Vladimir I. Titorenko   +1 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

PHENOTYPIC AND METABOLIC FEATURES OF CD4 AND CD8 T CELLS OF AN ELITE CONTROLLER

Problems of Infectious and Parasitic Diseases
Background: People living with HIV (PLHIV) who are capable of long-term viral suppression in the absence of antiretroviral therapy (ART) are defined as elite controllers (EC).
Damian Vangelov, Radoslava Emilova, Yana Todorova, Svetla Blazheva, Ivailo Alexiev, Tsetsa Doichinova, Maria Nikolova   +6 more
doaj   +1 more source

Effects of disialoganglioside GD3 on the mitochondrial membrane potential

FEBS Letters, 2005
GD3 is an intracellular mediator of apoptotic signaling. Although GD3 is known to directly act on mitochondria, the dynamic responses of individual mitochondria to GD3 remain to be elucidated. In the current study, the membrane potential of single mitochondria is observed in the presence of GD3 or its analogues.
Higuchi, Yu, Miura, Tsuyoshi, Kajimoto, Tetsuya, Ohta, Yoshihiro   +3 more
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

hUCMSC mitochondrial EVs confer neuroprotection after ischemia by Tom1l2-mediated mitochondrial fusion and Crls1–cardiolipin axis reprogramming

Redox Biology
Mitochondrial dysfunction is a central driver of irreversible neuronal injury following ischemic stroke (IS); yet effective strategies to restore mitochondrial function and promote long-term neurological recovery remain limited.
Ziheng Li, Xingjia Zhu, Weiquan Liao, Rui Jiang, Enze Sang, Jue Zhu, Gaojia Sun, Zhichao Lu, Chenxing Wang, Yi Jiang, Jian Chen, Peipei Gong, Qianqian Liu   +12 more
doaj   +1 more source

Electrical homeostasis of the inner mitochondrial membrane potential

Physical Biology
Abstract The electric potential across the inner mitochondrial membrane must be maintained within certain bounds for the proper functioning of the cell. A feedback control mechanism for the homeostasis of this membrane potential is proposed whereby an increase in the electric field decreases the rate-limiting steps of the electron ...
Peyman Fahimi, Lázaro A M Castanedo, P Thomas Vernier, Chérif F Matta   +3 more
openaire   +3 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source