Results 61 to 70 of about 10,023,283 (299)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Membrane fouling in osmotically driven membrane processes: A review

, 2016
The utilization of osmosis for engineered applications sparked off various emerging technologies relying on osmotically driven membrane processes (ODMPs).
Fane, Anthony Gordon, Tang, C, She, Q, Wang, Rong, She, Qianhong, Tang, Chuyang Y., Wang, R, Fane, AG   +7 more
core   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Solubilization of lipids and membrane proteins into nanodiscs: Mode of action and applications of SMA copolymers [PDF]

, 2016
Cell membranes separate the inside and outside of cells. Membrane proteins in the cell membrane control the traffic of molecules across the membrane and are therefore targets for a lot of drugs: about 50 % of all approved drugs target a membrane protein!
Scheidelaar, S., Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics   +2 more
core  

A tight polyethersulfone ultrafiltration membrane fabricated via polyion complex assisted phase inversion for dye desalination

, 2023
In this work, a tight polyethersulfone (PES) -based ultrafiltration (UF) membrane was fabricated to separate dye and salt of textile wastewater via a novel polyion complex assisted phase inversion method in one step.
Yali Zhao, Zhao, Yali, Gwo Sung Lai, Rong Wang, Wang, Rong, Yurong Yin, Lai, Gwo Sung, Yin, Yurong, Yuan Liao, Liao, Yuan   +9 more
core   +1 more source

Molecular Dynamics Simulation Study of Solid Vibration Permeation in Microporous Amorphous Silica Network Voids

Membranes, 2019
Microporous silica membranes have silica polymer network voids smaller than 3 Å where only small gas molecules such as helium (2.6 Å) and hydrogen (2.89 Å) can be transported.
Tomohisa Yoshioka, Akihiro Nakata, Kuo-Lun Tung, Masakoto Kanezashi, Toshinori Tsuru   +4 more
doaj   +1 more source

Activation of Mitochondrial Ca2+ Oscillation and Mitophagy Induction by Femtosecond Laser Photostimulation

Bio-Protocol, 2022
Ultra-precise stimulation solely to individual mitochondria, without any influence to the whole cell, is quite difficult by traditional biochemical reagents. In mitophagy research, the mitochondria and even the whole cell usually suffer irreversible
Xiaoying Tian, Hao He
doaj   +1 more source

Discrepancies Between Micro Versus Macroscale Viscoelastic Properties in a Microplastic‐Tissue Composite Model

Advanced Engineering Materials, EarlyView.
This study explores the discrepancies between bulk mechanics and spatial mapping in a tissue‐mimetic hydrogel model. Microplastic particles create localized stiff mechanical microenvironments that are detectable by cellular‐scale nanoindentation but leave bulk properties unchanged as measured by rheology.
Ahron T. Verschleisser, Baptiste Le Roi, Omri Leshem, Joshua M. Grolman   +3 more
wiley   +1 more source

Speeding-up Screening of S1 SARS-CoV2 Inhibitors by Nanostructured Biomimetic ACE2 Sensors Based on a Superconductive Josephson Junction Toroidal Array Oscillating Effect

ECS Sensors Plus
We present a method for integrating a quantum superconductive oscillation effect, induced by a potential S1 SARS-CoV-2 inhibitor, which achieves a 99.992% blockade of S1 virus communication with a biomimetic angiotensin-converting enzyme 2 (ACE2) sensor.
Ellen T. Chen, John T. Thornton
doaj   +1 more source

DC-shifts in amplitude in-field generated by an oscillatory interference model of grid cell firing

Frontiers in Systems Neuroscience, 2014
Oscillatory interference models propose a mechanism by which the spatial firing pattern of grid cells can arise from the interaction of multiple oscillators that shift in relative phase. These models produce aspects of the physiological data such as the
Angela Christine Elizabeth Onslow, Michael E Hasselmo, Ehren Lee Newman   +2 more
doaj   +1 more source