Results 41 to 50 of about 10,028,621 (303)

Relationship among surface electric double layer of cardiomyocyte membrane and toxicology of digoxin and opening of ion channels

open access: yesScientific Reports, 2022
We applied a new idea that the potential effect can change the ion adsorption structure on the cell surface to explore the mechanism of digoxin poisoning and the regulation of ion channels.
Ying Zhou   +5 more
doaj   +1 more source

Generation and Preservation of the Slow Underlying Membrane Potential Oscillation in Model Bursting Neurons

open access: yes, 2010
The underlying membrane potential oscillation of both forced and endogenous slow-wave bursting cells affects the number of spikes per burst, which in turn affects outputs downstream. We use a biophysical model of a class of slow-wave bursting cells with
Clarence C. Franklin   +3 more
core   +1 more source

Membrane defouling using microbubbles generated by fluidic oscillation [PDF]

open access: yes, 2018
Impurities and colloidal substances are two of many fouling conditions that reduce the membrane filtration performance used in wastewater treatment. This study investigates the potential of fluidic-oscillation-generated microbubbles (MBs) to defoul the ...
William B. Zimmerman, M. H. C. Harun
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Long-range correlation of the membrane potential in neocortical neurons during slow oscillation

open access: yes, 2011
Large amplitude slow waves are characteristic for the summary brain activity, recorded as electroencephalogram (EEG) or local field potentials (LFP), during deep stages of sleep and some types of anesthesia.
Chauvette, Sylvain   +5 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

(a) Induced vessel oscillation at 0.2 Hz with vessel dilation for 0.5 s and corresponding (b) change in neuronal membrane potential bound by reversal potential of sodium and potassium channel.

open access: yes, 2012
(a) Induced vessel oscillation at 0.2 Hz with vessel dilation for 0.5 s and corresponding (b) change in neuronal membrane potential bound by reversal potential of sodium and potassium channel.
V. Srinivasa Chakravarthy (118750)   +1 more
core   +1 more source

Model Comparison with and without MinD-membrane-dissociation reactions of membrane-stable MinD states.

open access: yes, 2023
An asterisk (*) indicates that the model includes MinD-membrane-dissociation reactions of the membrane-stable MinD state, the reactions de → D+E and de → D+e for the SAM and the reactions ded → D+E+D, ded → D+E+d, ded → D+de, ded → D+e+D, and ded → D+e+d
William C. Carlquist (2412412)   +1 more
core   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

Elastic–Plastic Modeling and Experimental Characterization of Granular Jamming Actuators

open access: yesAdvanced Engineering Materials, EarlyView.
Granular jamming enables rapid switching between soft and rigid mechanical states. Here, a reduced‐order elastic‐perfectly‐plastic beam framework captures pressure‐dependent loading, unloading, residual deformation, and hysteresis in jammed beams, while matching three‐point bending experiments across materials and geometries. The framework links design
Saheli Patel   +2 more
wiley   +1 more source

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