Results 191 to 200 of about 217,002 (256)

Energy Landscape Analysis of Membrane Proteins Using NMR-Based Hybrid Restraint Potentials. [PDF]

J Chem Theory Comput
Dewan D, Wang Y, De Simone A, Wales DJ.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A biophysically grounded model of glutamatergic synaptic transmission integrating glutamate transport, receptor kinetics, and electrotonic effects. [PDF]

J Comput Neurosci
Chizhov AV, Malkin SL, Khachatryan DN, Zaitsev AV.   +3 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Beyond Membrane Potential: Exploiting Signal Complexity in Genetically Encoded Voltage Indicators. [PDF]

Sensors (Basel)
Frankiv N, Lee H, Baker BJ.
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

HAPQ: A Hardware-Aware Pruning and Quantization Pipeline for Event-Based SNN Detection. [PDF]

Sensors (Basel)
Li Z, Wu J.
europepmc   +1 more source

Spatially targeted inhibitory rhythms differentially affect neuronal integration. [PDF]

Elife
Headley DB, Latimer B, Aberbach A, Nair SS.   +3 more
europepmc   +1 more source

Frequency shaping of tactile perception via transcutaneous interferential electrical stimulation: a simulation study. [PDF]

Front Neurosci
Ohara H, Yoshimoto S, Asai Y, Ota T.
europepmc   +1 more source

Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humans. [PDF]

Neuro Oncol
Tong T, Hendriksen JD, Elbæk KJ, Molnar K, Christiansen FV, Ozsvar A, Eschen JT, Rodríguez-González FG, Pusat ID, Christensen EL, Rahbæk M, Frederiksen KP, Cortnum SOS, Sindby AK, Meier K, Nikola, Sørensen JCH, Ting JT, Capogna M, Kristensen BW, Nyengaard JR, Weischenfeldt J, Hou WH, Korshøj AR.   +23 more
europepmc   +1 more source