Results 281 to 290 of about 438,564 (323)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Monitoring of Bicelles Spreading into Floating Lipid Bilayers. [PDF]

Langmuir
Bożek J, Dziubak D, Grempka A, Sek S, Brand I.   +4 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Spatially Resolved Ion Sensing by Voltammetric Ion Transfer Microscopy. [PDF]

JACS Au
Mattos GJ, Rothen JA, Cherubini TJ, Bakker E.   +3 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence. [PDF]

Front Behav Neurosci
Tomasch M, Naess E, McComas S, Burman MA.   +3 more
europepmc   +1 more source

Unlocking cathodic potential dependent Pd deactivation for energy efficient CO₂ electroreduction to formate. [PDF]

Nat Commun
Chen J, Aliasgar M, Zhao Y, Zamudio FB, Fan L, Chen J, Chen J, Gu X, Gao J, Kozlov SM, Wang L.   +10 more
europepmc   +1 more source

Characterization of optogenetically activated inhibitory inputs onto cholinergic motor neurons in the spinal dorsolateral nucleus. [PDF]

Physiol Rep
Kamijo TC, Karnup S, Matsuoka K, Kimura S, Miyazato M, Daugherty SL, Beckel JM, Yoshimura N.   +7 more
europepmc   +1 more source

Ionic mechanisms underlying bistability in spinal motoneurons: insights from a computational model. [PDF]

Front Cell Neurosci
Molkov YI, Krust F, Jeter R, Stell T, Mohammed MAY, Brocard F, Rybak IA.   +6 more
europepmc   +1 more source

Sinoatrial Node Dynamics: Clinical Relevance and microRNA-Based Modulation of Pacemaker Activity. [PDF]

Cureus
Nur H.
europepmc   +1 more source