Results 321 to 330 of about 12,112,951 (393)

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

Pregnenolone sulfate potentiates tetrodotoxin-resistant Na⁺ channels to increase the excitability of dural afferent neurons in rats. [PDF]

J Headache Pain
Jang IS, Nakamura M.
europepmc   +1 more source

Transport Numbers and Electroosmosis in Cation-Exchange Membranes with Aqueous Electrolyte Solutions of HCl, LiCl, NaCl, KCl, MgCl₂, CaCl₂ and NH₄Cl. [PDF]

Entropy (Basel)
Solberg SBB, Deress ZB, Hvamstad MH, Burheim OS.   +3 more
europepmc   +1 more source

The molecular transition that confers voltage dependence to muscle contraction. [PDF]

Nat Commun
Angelini M, Savalli N, Steccanella F, Maxfield S, Pozzi S, DiFranco M, Cannon SC, Pantazis A, Olcese R.   +8 more
europepmc   +1 more source

Modeling analysis of depolarization-assisted afterdischarge in hippocampal mossy fibers. [PDF]

Front Neural Circuits
Kamiya H.
europepmc   +1 more source

The Role of Anode Potential in Electromicrobiology. [PDF]

Microorganisms
Li Y, Zong Y, Feng C, Zhao K.
europepmc   +1 more source

The roles of feedback loops in the Caenorhabditis elegans rhythmic forward locomotion. [PDF]

PLoS Comput Biol
Zhao P, Wang B, Rong Y, Yuan Y, Liu J, Huo H, Liu Z, Li Z, Fang T.   +8 more
europepmc   +1 more source

Showcasing the Comprehensive Understanding of Cellular Profiling and Human Neurophysiology.

J Pharm Bioallied Sci
Jadhav D, Ambad RS.
europepmc   +1 more source