Results 51 to 60 of about 438,564 (323)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Intrinsic Moment of Inertia of Membranes as bounds for the mass gap of Yang-Mills Theories [PDF]

, 2006
We obtain the precise condition on the potentials of Yang-Mills theories in 0+1 dimensions and D0 brane quantum mechanics ensuring the discretness of the spectrum. It is given in terms of a moment of inertia of the membrane. From it we obtain a bound for
A. Restuccia, A.J. Pérez, Bellorin, Boulton, Boulton, Claudson, de Wit, de Wit, de Wit, Gabadadze, Garcia del Moral, L. Navarro, Lüscher, M.P. Garcia del Moral, Mazy'a, Molchanov, Nicolai, Simon   +17 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Detection of Membrane Potential in Mycobacterium tuberculosis

Bio-Protocol, 2013
DiOC2 (Novo et al., 2000) exhibits green fluorescence in all bacterial cells, but the fluorescence shifts towards red emission as the dye molecules self associate at the higher cytosolic concentrations caused by larger membrane potentials.
Manbeena Chawla, Amit Singh
doaj   +1 more source

Modeled channel distributions explain extracellular recordings from cultured neurons sealed to microelectrodes [PDF]

, 2002
Amplitudes and shapes of extracellular recordings from single neurons cultured on a substrate embedded microelectrode depend not only on the volume conducting properties of the neuron-electrode interface, but might also depend on the distribution of ...
Buitenweg, Jan Reinoud, Marani, Enrico, Rutten, Wim L.C.   +2 more
core   +3 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Stochastic Dynamics of Electrical Membrane with Voltage-Dependent Ion Channel Fluctuations

, 2014
Brownian ratchet like stochastic theory for the electrochemical membrane system of Hodgkin-Huxley (HH) is developed. The system is characterized by a continuous variable $Q_m(t)$, representing mobile membrane charge density, and a discrete variable $K_t$
Qian, Hong, Qian, Min, Zhang, Xue-Juan
core   +1 more source

Consequences of converting graded to action potentials upon neural information coding and energy efficiency [PDF]

, 2014
Information is encoded in neural circuits using both graded and action potentials, converting between them within single neurons and successive processing layers. This conversion is accompanied by information loss and a drop in energy efficiency.
A Borst, A Destexhe, A Hasenstaub, A Manwani, A Manwani, A Treves, AA Lazar, AA Lazar, AA Lazar, AL Hodgkin, AS French, B Aguera y Arcas, B Sengupta, B Sengupta, B Sengupta, B Sengupta, B Sengupta, BA Olshausen, BC Carter, Biswa Sengupta, C Koch, C Koch, C Shannon, CC Chow, D Attwell, D Desmaisons, D Lee, DM MacKay, DT Gillespie, E Marder, E Salinas, E Schneidman, E Skaugen, EM Izhikevich, F Theunissen, FA Dodge Jr, G Laurent, G Marsaglia, GG de Polavieja, H Alle, H Alle, J Haag, JA White, JA White, JC Rekling, JC Skou, JD Victor, JD Victor, JE Niven, JE Niven, JE Niven, JE Niven, JE Niven, Jeremy Edward Niven, K Koch, M Juusola, M Matsumoto, M Pinsker, M Stemmler, MB Kennel, ME Larkum, MH Kole, MN Shadlen, MS Grubb, MV Srinivasan, NJ Lenn, O Bernander, Olaf Sporns, PG Lillywhite, PN Steinmetz, R Guttman, R Sarpeshkar, RA DiCaprio, RRdR van Steveninck, S Curti, S Laughlin, SB Laughlin, Simon Barry Laughlin, SP Strong, SR Williams, TJ Gawne, V Prelov, W Singer, Y Shu, ZF Mainen   +84 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source