Results 61 to 70 of about 12,231,174 (337)

Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials

The Journal of General Physiology, 1988
Planar lipid bilayer recordings were used to study Ca channels from bovine cardiac sarcolemmal membranes. Ca channel activity was recorded in the absence of nucleotides or soluble enzymes, over a range of membrane potentials and ionic conditions that ...
Robert L. Rosenberg, Peter Hess, Richard W. Tsien   +2 more
semanticscholar   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Accelerating compartmental modeling on a graphical processing unit

Frontiers in Neuroinformatics, 2013
Compartmental modeling is a widely used tool in neurophysiology but the detail and scope of such models is frequently limited by lack of computational resources. Here we implement compartmental modeling on low cost Graphical Processing Units (GPUs).
Roy eBen-Shalom, Roy eBen-Shalom, Gilad eLiberman, Alon eKorngreen, Alon eKorngreen   +4 more
doaj   +1 more source

Analyzing the effect of ion binding to the membrane-surface on regulating the light-induced transthylakoid electric potential (ΔΨm)

Frontiers in Plant Science, 2022
The transthylakoid membrane potential (ΔΨm) is essential because it can drive the ATP synthesis through the CF0–CF1 type of ATP-synthase in chloroplasts as an energetic equivalent similar to ΔpH.
Hui Lyu, Dušan Lazár
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Imaging mitochondrial membrane potentials

Biophysical Journal, 1993
process remain to be elucidated. The elusiveness of this goal can be attributed, at least in part, to the absence of structural information about the mitochondrion itself at several levels of complexity. It is obvious, for example, that obtaining atomic structures of the respiratory chain protein complexes by x-ray or electron crystallography would ...
openaire   +3 more sources

Synaptic Interactions between Primate Precentral Cortex Neurons Revealed by Spike-Triggered Averaging of Intracellular Membrane Potentials In Vivo

Journal of Neuroscience, 1996
To document synaptic interactions between neurons in the precentral cortex of macaque monkeys, we recorded in vivo the intracellular (IC) membrane potentials of cortical neurons simultaneously with extracellular (EC) action potentials of neighboring ...
M. Matsumura, Dao-fen Chen, T. Sawaguchi, K. Kubota, E. Fetz   +4 more
semanticscholar   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Insight into the Mode of Action of Celangulin V on the Transmembrane Potential of Midgut Cells in Lepidopteran Larvae

Toxins, 2017
Celangulin V (CV) is the main insecticidal constituent of Celastrus angulatus. The V-ATPase H subunit of the midgut cells of lepidopteran larvae is the putative target protein of CV.
Yingying Wang, Jiwen Zhang, Mingxing Feng, Wenjun Wu, Zhaonong Hu   +4 more
doaj   +1 more source

Dependence of serosal membrane potential on mucosal membrane potential in toad urinary bladder

Biophysical Journal, 1975
Ussing's model for sodium transport across epithelia assumes the existence of two barriers in series; the outer barrier behaves as a sodium electrode and the inner barrier as a potassium electrode (Koefoed-Johnsen and Ussing, 1958); furthermore, these membranes are supposed to be independent of one another.
A.L. Finn, L. Reuss
openaire   +3 more sources