Results 171 to 180 of about 2,329,860 (269)

Integrative Single-Cell Analysis Reveals Targetable Vacuole Membrane Protein 1-Mediated Mechanism of Tumor Angiogenesis in Glioblastoma. [PDF]

MedComm (2020)
Jin L, Chen B, Liao J, Guo W, Zhu Z, Ali S, Leung GK, Wang P, Kiang KM.   +8 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

<i>Pseudomonas aeruginosa</i> DEV phage exploits the essential LptD outer membrane protein as receptor for adsorption. [PDF]

mBio
Nieto Noblecia J, Bellis NF, Antichi CA, Aminian S, Forti F, Falchi FA, Sposato D, Imperi F, Cingolani G, Briani F.   +9 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Selenoprotein K Is a Peripheral ER Membrane Protein. [PDF]

Biochemistry
Odunsi A, Rahmani E, Ghelichkhani F, Romero B, Batish M, Rozovsky S.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Engineering <i>Escherichia coli</i> for polyethylene terephthalate powder biodegradation via recoding of an outer membrane protein. [PDF]

iScience
Giménez-Dejoz J, Vidal P, Romero S, Almendral D, Luengo M, Martinez-Sugrañes M, Gonzalez-Alfonso JL, Robles-Martín A, Plou FJ, Bargiela R, Floor M, Ferrer M, Guallar V, Fernandez-Lopez L.   +13 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Rules of Engagement for Components of Membrane Protein Biogenesis at the Human Endoplasmic Reticulum. [PDF]

Int J Mol Sci
Zimmermann R.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source