Results 11 to 20 of about 2,329,860 (269)
Scientific Reports, 2021 Trichoderma reesei is an ascomycete fungus known for its capability to secrete high amounts of extracellular cellulose- and hemicellulose-degrading enzymes. These enzymes are utilized in the production of second-generation biofuels and T.
Sami Havukainen +5 more
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Communications Biology, 2021 Guan and Hariharan report two crystal structures of melibiose transporter MelB in complex with substrate analogs, nitrophenyl-galactoside, and dodecyl-melibioside.
Lan Guan, Parameswaran Hariharan
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Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein
Frontiers in Molecular Biosciences, 2023 P-glycoprotein (Pgp) is a multidrug transporter that uses the energy from ATP binding and hydrolysis to export from cells a wide variety of hydrophobic compounds including anticancer drugs, and mediates the bioavailability and pharmacokinetics of many ...
Nghi N. B. Tran +10 more
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Role of PKD2 in the endoplasmic reticulum calcium homeostasis
Frontiers in Physiology, 2022 Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in the PKD1 or PKD2 gene which encodes membrane receptor PKD1 and cation channel PKD2, respectively. PKD2, also called transient receptor potential polycystin-2 (TRPP2), is a Ca2+
Xiong Liu, Jingfeng Tang, Xing-Zhen Chen
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Polymer-encased nanodiscs with improved buffer compatibility
Scientific Reports, 2017 Styrene-maleic acid copolymers allow for solubilization and reconstitution of membrane proteins into nanodiscs. These polymer-encased nanodiscs are promising platforms for studies of membrane proteins in a near-physiologic environment without the use of ...
Mariana C. Fiori +3 more
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Cells, 2021 Zinc constitutes the second most abundant transition metal in the human body, and it is implicated in numerous cellular processes, including cell division, DNA and protein synthesis as well as for the catalytic activity of many enzymes.
Eva Ramos Becares +3 more
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Membrane protein secretases [PDF]
Biochemical Journal, 1997 A diverse range of membrane proteins of Type I or Type II topology also occur as a circulating, soluble form. These soluble forms are often derived from the membrane form by proteolysis by a group of enzymes referred to collectively as ‘secretases‘ or ‘sheddases’.
N M, Hooper, E H, Karran, A J, Turner
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Substrate-induced conformational dynamics of the dopamine transporter
Nature Communications, 2019 The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced
Anne Kathrine Nielsen +6 more
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Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms
Nature Communications, 2022 Here, the authors study ion transport mechanisms by introducing mutations to convert an electroneutral proton/potassium pump into a prototypical electrogenic sodium/potassium pump, explaining their selectivity and phosphorylation mechanisms.
Victoria C. Young +6 more
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Membrane-bending proteins [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2009 Cellular membranes can assume a number of highly dynamic shapes. Many cellular processes also require transient membrane deformations. Membrane shape is determined by the complex interactions of proteins and lipids. A number of families of proteins that directly bend membranes have been identified.
William A, Prinz, Jenny E, Hinshaw
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