Results 11 to 20 of about 2,314,591 (317)
Allostery in membrane proteins [PDF]
Current Opinion in Structural Biology, 2020 Membrane proteins are an integral part of signal transduction. To signal, membrane proteins must interact with a variety of lipid species, effectors, and other proteins in the biological membrane leading to an immense number of possible interactions. Despite this inherent complexity, accurate control of signaling must take place.
Zoe Cournia, Alexios Chatzigoulas
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Communications Biology, 2021 Guan and Hariharan report two crystal structures of melibiose transporter MelB in complex with substrate analogs, nitrophenyl-galactoside, and dodecyl-melibioside.
Lan Guan, Parameswaran Hariharan
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Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein
Frontiers in Molecular Biosciences, 2023 P-glycoprotein (Pgp) is a multidrug transporter that uses the energy from ATP binding and hydrolysis to export from cells a wide variety of hydrophobic compounds including anticancer drugs, and mediates the bioavailability and pharmacokinetics of many ...
Nghi N. B. Tran +10 more
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Role of PKD2 in the endoplasmic reticulum calcium homeostasis
Frontiers in Physiology, 2022 Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in the PKD1 or PKD2 gene which encodes membrane receptor PKD1 and cation channel PKD2, respectively. PKD2, also called transient receptor potential polycystin-2 (TRPP2), is a Ca2+
Xiong Liu, Jingfeng Tang, Xing-Zhen Chen
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Diffusion of Integral Membrane Proteins in Protein-Rich Membranes
The Journal of Physical Chemistry Letters, 2017 The lateral diffusion of embedded proteins along lipid membranes in protein-poor conditions has been successfully described in terms of the Saffman-Delbrück (SD) model, which predicts that the protein diffusion coefficient D is weakly dependent on its radius R as D ∝ ln(1/R).
Hector Martinez-Seara +4 more
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Cells, 2021 Zinc constitutes the second most abundant transition metal in the human body, and it is implicated in numerous cellular processes, including cell division, DNA and protein synthesis as well as for the catalytic activity of many enzymes.
Eva Ramos Becares +3 more
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Polymer-encased nanodiscs with improved buffer compatibility
Scientific Reports, 2017 Styrene-maleic acid copolymers allow for solubilization and reconstitution of membrane proteins into nanodiscs. These polymer-encased nanodiscs are promising platforms for studies of membrane proteins in a near-physiologic environment without the use of ...
Mariana C. Fiori +3 more
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Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms
Nature Communications, 2022 Here, the authors study ion transport mechanisms by introducing mutations to convert an electroneutral proton/potassium pump into a prototypical electrogenic sodium/potassium pump, explaining their selectivity and phosphorylation mechanisms.
Victoria C. Young +6 more
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Modeling the Membrane Environment for Membrane Proteins [PDF]
Biophysical Journal, 2011 Increasingly, the membrane protein community is recognizing the sensitivity of protein structure and function to the protein's environment. Hofer et al. (1), in their recent Letter in the Biophysical Journal, aim to develop a crystallization protocol that will have increased biological relevance.
Timothy A. Cross +4 more
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Substrate-induced conformational dynamics of the dopamine transporter
Nature Communications, 2019 The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced
Anne Kathrine Nielsen +6 more
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