Results 11 to 20 of about 1,865,200 (318)
Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein
Frontiers in Molecular Biosciences, 2023 P-glycoprotein (Pgp) is a multidrug transporter that uses the energy from ATP binding and hydrolysis to export from cells a wide variety of hydrophobic compounds including anticancer drugs, and mediates the bioavailability and pharmacokinetics of many ...
Nghi N. B. Tran +10 more
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Intercalated Cells: More than pH Regulation
Diseases, 2014 The renal collecting duct is the nephron segment where the final urine content of acid equivalents and inorganic ions are determined. The role of two different cell types present in this nephron segment has been determined many years ago: principal cells
Ensaf Y. Almomani +3 more
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Role of PKD2 in the endoplasmic reticulum calcium homeostasis
Frontiers in Physiology, 2022 Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in the PKD1 or PKD2 gene which encodes membrane receptor PKD1 and cation channel PKD2, respectively. PKD2, also called transient receptor potential polycystin-2 (TRPP2), is a Ca2+
Xiong Liu, Jingfeng Tang, Xing-Zhen Chen
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Cells, 2021 Zinc constitutes the second most abundant transition metal in the human body, and it is implicated in numerous cellular processes, including cell division, DNA and protein synthesis as well as for the catalytic activity of many enzymes.
Eva Ramos Becares +3 more
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Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms
Nature Communications, 2022 Here, the authors study ion transport mechanisms by introducing mutations to convert an electroneutral proton/potassium pump into a prototypical electrogenic sodium/potassium pump, explaining their selectivity and phosphorylation mechanisms.
Victoria C. Young +6 more
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Diffusion of Integral Membrane Proteins in Protein-Rich Membranes
The Journal of Physical Chemistry Letters, 2017 The lateral diffusion of embedded proteins along lipid membranes in protein-poor conditions has been successfully described in terms of the Saffman-Delbrück (SD) model, which predicts that the protein diffusion coefficient D is weakly dependent on its radius R as D ∝ ln(1/R).
Hector Martinez-Seara +4 more
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Polymer-encased nanodiscs with improved buffer compatibility
Scientific Reports, 2017 Styrene-maleic acid copolymers allow for solubilization and reconstitution of membrane proteins into nanodiscs. These polymer-encased nanodiscs are promising platforms for studies of membrane proteins in a near-physiologic environment without the use of ...
Mariana C. Fiori +3 more
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Modeling the Membrane Environment for Membrane Proteins [PDF]
Biophysical Journal, 2011 Increasingly, the membrane protein community is recognizing the sensitivity of protein structure and function to the protein's environment. Hofer et al. (1), in their recent Letter in the Biophysical Journal, aim to develop a crystallization protocol that will have increased biological relevance.
Timothy A. Cross +4 more
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Substrate-induced conformational dynamics of the dopamine transporter
Nature Communications, 2019 The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced
Anne Kathrine Nielsen +6 more
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Membrane systems with proteins embedded in membranes
Theoretical Computer Science, 2008 Membrane computing is a biologically inspired computational paradigm. Motivated by brane calculi we investigate membrane systems which differ from conventional membrane systems by the following features: (1) biomolecules (proteins) can move through the regions of the systems, and can attach onto (and de-attach from) membranes, and (2 ...
Brijder R. +4 more
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