Results 201 to 210 of about 9,802,116 (429)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Rational design of chemical- and light-inducible cGAS activation based on mechanistic insights

open access: yesCommunications Biology
Cyclic GMP-AMP synthase (cGAS) plays a pivotal role in the cGAS-STING pathway as a DNA sensor that binds to double-stranded DNA (dsDNA) and subsequently induces type I interferon expression, thereby contributing significantly to the innate immune ...
Yiting Tang, Wenjuan Wang, Chunlai Chen
doaj   +1 more source

Lipid-Assisted Membrane Protein Folding and Topogenesis

open access: yesThe Protein Journal, 2019
W. Dowhan, H. Vitrac, M. Bogdanov
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

The role of interfacial lipids in stabilizing membrane protein oligomers

open access: yesNature, 2017
Kallol Gupta   +9 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

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