Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Optimizing a coarse-grained model for large-scale membrane protein simulation. [PDF]
Biophys Rep (N Y)Wen CY, Luo YL, Madsen JJ.
europepmc +1 more source
Discovery of Specialized Basement Membrane Zone Proteins and their Alterations in Epidermolysis Bullosa [PDF]
, 2008 Guerrino Meneguzzi
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Effects of Lipopolysaccharide Core Modulation on Outer Membrane Protein Function and Virulence in Pectobacterium carotovorum. [PDF]
Mol Plant PatholPark Y, Hwang J, Choi J, Goo E, Lee JH.
europepmc +1 more source
Could maternal autoantibodies against folate receptor-membrane proteins cause spontaneous abortion or congenital heart defects? [PDF]
, 2006 Alan Neuman +7 more
openalex +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development. [PDF]
PLoS BiolRestrepo LJ +3 more
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation
, 2004 Michael S. D. Agus +3 more
openalex +2 more sources