Results 231 to 240 of about 9,802,116 (429)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Bacteriophage-resistant mutants of Salmonella typhimurium deficient in two major outer membrane proteins [PDF]

, 1976
Marjatta Nurminen, Kari Lounatmaa, Matti Sarvas, P. Helena Mäkelä, Taiji Nakae   +4 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

The role of inner nuclear membrane protein emerin in myogenesis. [PDF]

FASEB J
Marano N, Holaska JM.
europepmc   +1 more source

Microviscosity of togavirus membranes studied by fluorescence depolarization: influence of envelope proteins and the host cell [PDF]

, 1976
N. F. Moore, Yechezkel Barenholz, R R Wagner   +2 more
openalex   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

Nature Communications, 2014
U. Weierstall, Daniel James, Chong Wang, T. White, Dingjie Wang, Wei Liu, J. Spence, R. Bruce Doak, G. Nelson, P. Fromme, R. Fromme, I. Grotjohann, Christopher Kupitz, N. Zatsepin, Haiguang Liu, S. Basu, Daniel Wacker, Gye Won Han, V. Katritch, S. Boutet, M. Messerschmidt, Garth J. Williams, J. Koglin, M. Marvin Seibert, M. Klinker, C. Gati, R. Shoeman, A. Barty, H. Chapman, R. Kirian, K. Beyerlein, R. Stevens, Dianfan Li, S. T. A. Shah, N. Howe, M. Caffrey, V. Cherezov   +36 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

A coronavirus assembly inhibitor that targets the viral membrane protein. [PDF]

Nature
Laporte M, Jochmans D, Bardiot D, Desmarets L, Debski-Antoniak OJ, Mizzon G, Abdelnabi R, Leyssen P, Chiu W, Zhang Z, Nomura N, Boland S, Ohto U, Stahl Y, Wuyts J, De Jonghe S, Stevaert A, van Hemert MJ, Bontes BW, Wanningen P, Groenewold GJM, Zegar A, Owczarek K, Joshi S, Koukni M, Arzel P, Klaassen H, Vanherck JC, Vandecaetsbeek I, Cremers N, Donckers K, Francken T, Van Buyten T, Rymenants J, Schepers J, Pyrc K, Hilgenfeld R, Dubuisson J, Bosch BJ, Van Kuppeveld F, Eydoux C, Decroly E, Canard B, Naesens L, Weynand B, Snijder EJ, Belouzard S, Shimizu T, Bartenschlager R, Hurdiss DL, Marchand A, Chaltin P, Neyts J.   +52 more
europepmc   +1 more source

Integration of a virus membrane protein intothe lipid bilayer of target cells as a prerequisite for immune cytolysis. Specific cytolysis after virosome- target cell fusion [PDF]

, 1978
Brør Morein, Dorothee Barz, Ulrich H. Koszinowski, Volker Schirrmacher   +3 more
openalex   +1 more source