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Protein transport across the ER membrane

Trends in Biochemical Sciences, 1990
Protein transport across the endoplasmic reticulum (ER) membrane may be divided into two phases: an initiation or targeting cycle, which has been fairly well characterized, and the actual transfer of the polypeptide chain through the membrane, the mechanism of which is still unknown.
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Protein Transport Across Membranes

2015
Mitochondria contain their own DNA, they divide throughout interphase and are distributed randomly between daughter cells during cell division. Most mitochondrial proteins are encoded in the nucleus and produced in the cytosol. They are then imported into the mitochondria via the TOM/TIM transport system, which recognises them by a specific ...
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Membrane transport proteins: implications of sequence comparisons

Current Opinion in Cell Biology, 1992
Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action.
J K, Griffith   +8 more
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Bacterial Membrane Transport Proteins

1976
Bacterial transport systems are historically associated with the acceptance of the idea that the crossing of the cell membrane by a physiologically significant solute was mediated by the specialized operation of a protein or an array of molecules including specific proteins.
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Transport proteins of the plant plasma membrane

Current Opinion in Cell Biology, 1996
Recently developed molecular and genetic approaches have enabled the identification and functional characterization of novel genes encoding ion channels, ion carriers, and water channels of the plant plasma membrane.
S M, Assmann, L L, Haubrick
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Electrophoretic Protein Transport in Gold Nanotube Membranes

Analytical Chemistry, 2003
Gold nanotube membranes are ideal model systems for exploring how pore size affects the rate and selectivity of protein transport in synthetic membranes. This is because these membranes have cylindrical, monodisperse pores (the nanotubes) with diameters that can be varied at will from tens of nanometers down to less than 1 nm.
Shufang, Yu   +2 more
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Visualization of membrane-associated folate transport proteins

Advances in Enzyme Regulation, 1989
Transport of Methotrexate (MTX) into cells, via the "reduced folate" transport system, is a critical factor in the effectiveness of the drug in cancer chemotherapy, and defective transport is one of the principal types of resistance to MTX. Probes capable of detecting membrane-associated folate transport proteins (ftp's) in individual cells are ...
L E, Pope   +5 more
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Water Transport Mediated by Other Membrane Proteins

2017
Water transport through membrane is so intricate that there are still some debates. (Aquaporins) AQPs are entirely accepted to allow water transmembrane movement depending on osmotic gradient. Cotransporters and uniporters , however, are also concerned in water homeotatsis.
Boyue, Huang   +2 more
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Glyoxysomal Membrane Electron Transport Proteins

1987
Experiments utilizing intact glyoxysomes isolated from castor bean endosperm on Percoll gradients indicate that the membrane NADH:ferricyanide reductase (FCR) and NADH:cytochrome c reductase (CCR) activities are differentially affected by trypsin and may be associated with proton fluxes.
D. G. Luster, R. P. Donaldson
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Membrane protein oligomeric structure and transport function

Nature, 1981
Proteins which traverse membranes tend to have a dimeric structure in which the dimer is arranged asymmetrically across the membrane with the axis of symmetry perpendicular to the membrane plane. This general structure is well suited to the function of transporting nutrients across the cell membrane.
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