Results 111 to 120 of about 2,399,625 (308)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Microwaves induced epitaxial growth of urchin like MIL-53(Al) crystals on ceramic supports

Scientific Reports
Shaping Metal–Organic Frameworks (MOFs) poses a significant challenge for their widespread application on a large scale. In particular, a precise control over crystal orientation and arrangement on substrates are expected to provide exiting opportunities
Limor Ben Neon, Martin Drobek, Mikhael Bechelany, Bertrand Rebiere, Anne Julbe   +4 more
doaj   +1 more source

Crystalline Structures and Properties of Uniaxial Oriented Poly(ethylene chlorotrifluoroethylene) Fiber

Cailiao gongcheng, 2016
Uniaxial oriented poly (ethylene chlorotrifluoroethylene) (ECTFE) fibers were prepared by the melt spinning method using ECTFE resin as the fiber-forming polymer.
PAN Jian, XIAO Chang-fa, ZHAO Jian, HUANG Qing-lin, REN Qian   +4 more
doaj   +1 more source

Modelling and Simulations of Multi-component Lipid Membranes and Open Membranes via Diffusive Interface Approaches [PDF]

, 2006
In this paper, phase field models are developed for multi-component vesicle membranes with different lipid compositions and membranes with free boundary.
Du, Qiang, Wang, Xiaoqiang
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A native CO2-reducing bacterium: Discovery, implementation and interests

Journal of CO2 Utilization
Stenotrophomonas maltophilia has been demonstrated herein to reduce CO2 without any cofactor, photon or hydrogen (H2) addition during reaction. S. maltophilia reduces 13CO2 into 13C-labeled formate in batch mode.
Azariel Ruiz-Valencia, Louis Cornette de Saint Cyr, Djahida Benmezianne, Eddy Petit, Loubna Karfane-Atfane, Héloïse Baldo, Valérie Bonniol, Sophie Pécastaings, Christine Roques, Delphine Paolucci-Jeanjean, José Sanchez-Marcano, Marie-Pierre Belleville, Laurence Soussan   +12 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. [PDF]

, 1980
Protease digestion of acetylcholine receptor-rich membranes derived from Torpedo californica electroplaques by homogenization and isopycnic centrifugation results in degradation of all receptor subunits without any significant effect on the appearance in
Heuser, JE, Klymkowsky, MW, Stroud, RM
core   +1 more source

Membrane transporters

European Journal of Pharmaceutical Sciences, 2000
Carrier-mediated drug transport is relatively unexplored in comparison with passive transcellular and paracellular drug transport. Yet, there is a host of transporter proteins that can be targeted for improving epithelial drug absorption. Generally, these are transport mechanisms for amino acids, dipeptides, monosaccharides, monocarboxylic acids ...
openaire   +2 more sources