Results 141 to 150 of about 3,092,461 (356)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Surface Modification of Cellulose Nanocrystal Films via RAFT Polymerization for Adsorption of PFAS

Polysaccharides
Cellulose nanocrystals (CNCs) are bio-based materials able to be functionalized following different approaches, which expands their range of applications.
Chaimaa Gomri, Belkacem Tarek Benkhaled, Arnaud Chaix, Eddy Petit, Marc Cretin, Mona Semsarilar   +5 more
doaj   +1 more source

1188 Disorganization of basement membrane zone architecture for impaired melanocyte inhabitation in vitiligo [PDF]

, 2023
F. Yang, L. Yang, Y. Kuroda, S. Lai, Y. Takahashi, T. Sayo, T. Namiki, K. Nakajima, S. Sano, S. Inuoe, D. Tsuruta, I. Katayama   +11 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Preparation and properties of TiO₂ blended silk fibroin grafted PAN filtration membrane

Cailiao gongcheng, 2019
Using organic solvent in traditional polymer filtration membrane is easy to cause environ-mental pollution.The silk was uniformly grafted with polyacrylonitrile using zinc chloride aqueous sol-ution as the solvent.
LI Shu-wen, ZHAO Kong-yin, CHEN Kang, LI Jin-gang, ZHAO Lei, WANG Xiao-lei, WEI Jun-fu   +6 more
doaj  

Oxalic acid crosslinked sodium alginate@Ag3PO4hydrogel membrane and its photocatalytic degradation for high salt dyes

Cailiao gongcheng
Semiconductor photocatalytic materials exhibit significant potential for application in environmental protection，attributed to their eco-friendly and energy-efficient attributes.
YANG Yabin, HAN Zhihui, QI Xingci, Wang Zijia, LI Qi, GONG Zelong, ZHAO Kongyin   +6 more
doaj   +1 more source

Theoretical and Experimental Study of Linear Momentum Contours in pristine and aged Nafion 117 Membranes [PDF]

, 2023
C.F. Zinola
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source