Results 41 to 50 of about 488,818 (300)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Memorial service: A means of communication with the dead [PDF]

open access: yesGlasnik Etnografskog Instituta SANU, 2005
A specific relationship toward the dead characterizes the traditional Serbian culture; this cult exists even today, in somewhat changed form. A death is always followed by the appropriate, traditional, ritual obligations that served to regulate behavior ...
Ivanović-Barišić Milina M.
doaj   +1 more source

Memento Mori : Memento Maori – moko and memory [PDF]

open access: yes, 2009
Moko patterns, mau moko, “wearing ink” is often explained as an act of remembrance, a symbol of honour or success, of grieving or loss. Memento mori, remembering the dead and remembrance of death, pervades the Maori world, and is profoundly expressed in ...
Te Awekotuku, Ngahuia
core   +1 more source

The Gosport War Memorial Hospital Panel report and its implications for nursing [PDF]

open access: yes, 2019
Where do we even begin? How do mere words encapsulate the full horror of the Gosport War Memorial Hospital (GWMH) report (Gosport Independent Panel, 2018) and its profound implications for nursing?
Catchpole   +20 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

East of the West: Repossessing the Past In India [PDF]

open access: yes, 2018
Public history, as it is practised in India, defies easy attempts at classification. This is partially because hardly anything that would be recognised as public history is identified as such by its author(s).
Chowdhury, Indira, Mandal, Srijan
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Muslim Tombstones of Kamak (Turkestan Region) as a Historical and Archaeological Source

open access: yesПоволжская археология, 2021
In 2013, an archaeological and ethnographic expedition of the Scientific Research Institute of Culture LLP explored the southern regions of Kazakhstan. The main priority was given to field research on the issues of archaeology, ethnography, culture and ...
Baigunakov Dosbol S.   +1 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Usos públicos de passados ditatoriais: Visualizações na Alemanha [PDF]

open access: yes, 2016
This article aims to reconstruct the visualization of the past in Germany between 1945 and 2005. The remembrances of the National Socialism shows the myriad ways in which Germans have sought to memorialize this dark part of their history.
Svampa, María Lucila
core   +2 more sources

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