Results 51 to 60 of about 46,773 (293)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Il Memoriale dell’Amnistia politica brasiliana: contesa simbolica e legittimità nella città delle “libertà” [PDF]
Diacronie. Studi di Storia Contemporanea, 2015 This article aims to analyze the political discourse around the implementation of the Brazilian Political Amnesty Memorial, in Belo Horizonte, state of Minas Gerais.
Priscila Cabral Almeida
doaj
Music, emotion and remembrance: unveiling memorials to the fallen of the First World War in Scotland [PDF]
, 2018 The unveiling of memorials to those who fell in World War One were highly solemn, dramatic and emotional events. Yet while much attention has been given by historians to memorials and the purposes behind memorialisation, there has been less discussion ...
Smyth, James
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The Importance of Beloved’s Magical Feminism in Understanding the Function of Memorials [PDF]
Akofena: Memorial architecture has gained significance in helping communities recover from collective trauma, with memory becoming a central concept in studies of traumatic events.
Yassmine BOUKHALKHAL & Djamel Eddine BELABDLI
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Études ÉcossaisesUntil very recently, Glasgow remained the only city in the world with a significant Irish diaspora but without a Great Famine memorial; and yet today, it is home to not one, but two such memorials: an Irish and Scottish Highland memorial inaugurated in ...
Nathalie Duclos
doaj +1 more source
Impacting Education, 2020 The Ed.D. program in Heritage Leadership for Sustainability, Social Justice, and Participatory Culture at the University of Missouri—St. Louis helps students cultivate the mindsets and skill sets required to sustain, pluralize, and enliven heritage in ...
Theresa G. Coble +3 more
doaj +1 more source