Results 51 to 60 of about 28,144 (310)
Il Memoriale dell’Amnistia politica brasiliana: contesa simbolica e legittimità nella città delle “libertà” [PDF]
Diacronie. Studi di Storia Contemporanea, 2015 This article aims to analyze the political discourse around the implementation of the Brazilian Political Amnesty Memorial, in Belo Horizonte, state of Minas Gerais.
Priscila Cabral Almeida
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Importance of Beloved’s Magical Feminism in Understanding the Function of Memorials [PDF]
Akofena: Memorial architecture has gained significance in helping communities recover from collective trauma, with memory becoming a central concept in studies of traumatic events.
Yassmine BOUKHALKHAL & Djamel Eddine BELABDLI
doaj +1 more source
Acta Structilia, 2020 At the dawn of democracy in 1994, the nation was seeking a new identity and for many South Africans it was to be an identity based on their African culture and tradition.
Graham Young, Piet Vosloo
doaj +1 more source
Making sense of Australia's war memorials
, 2010 War memorials are an important part of the Australian landscape and culture. This essay suggests five possible explanations for this: \ud \ud a) imperial loyalty, at least initially; \ud b) the warrior cult; \ud c) guilt at the loss of so many young ...
Page, James Smith, James Page
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Memorials : Associative Meanings
, 2020 This chapter explores the relationship between memorials and their locations, virtual and physical, with an emphasis on the importance of the latter for analysis.
Peniston-Bird, C.M. +2 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source