Results 61 to 70 of about 4,743,433 (368)
Nature Communications, 2020 Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.
Ping-Chieh Pao +17 more
doaj +1 more source
Spin and charge drift-diffusion in ultra-scaled MRAM cells
Scientific Reports, 2022 Designing advanced single-digit shape-anisotropy MRAM cells requires an accurate evaluation of spin currents and torques in magnetic tunnel junctions (MTJs) with elongated free and reference layers.
Simone Fiorentini +6 more
doaj +1 more source
Breaking Down Memory Walls: Adaptive Memory Management in LSM-based Storage Systems (Extended Version) [PDF]
arXiv, 2020 Log-Structured Merge-trees (LSM-trees) have been widely used in modern NoSQL systems. Due to their out-of-place update design, LSM-trees have introduced memory walls among the memory components of multiple LSM-trees and between the write memory and the buffer cache.
arxiv
Lynching, Memory and Memorials [PDF]
Polish Journal for American Studies, 2019 This article touches upon three important topics: lynching, memory, and memorialization-looked at from the perspective of the twenty-first century. As far as lynching is concerned, it focuses on a significant growth of interest in this painful historical, social, and political issue.
openaire +1 more source
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, EarlyView.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
Alzheimer’s Research & Therapy, 2021 Background β-amyloid (Aβ) and tau positron emission tomography (PET) detect the pathological changes that define Alzheimer’s disease (AD) in living people.
Elena Tsoy +11 more
doaj +1 more source
Memory, space and time: Researching children's lives [PDF]
, 2010 This article discusses the research approach in 'Pathways through Childhood', a small qualitative study drawing on memories of childhood. The research explores how wider social arrangements and social change influence children's everyday lives.The ...
Adam, B. +18 more
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Social work and families in child welfare in Malawi
Journal of Comparative Social Work, 2015 This article discusses professional discretion in relation to placing a child outside the family, as understood by Malawian social workers. The article is a product of an exploratory study covering different aspects of social work practice with children
Memory Jayne Tembo, Siv Oltedal
doaj +1 more source
EMBO Molecular Medicine, 2021 PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)‐related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment
Rik Ossenkoppele +15 more
doaj +1 more source