Results 51 to 60 of about 3,006,221 (300)

Detecting Alzheimer’s disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET

Alzheimer’s Research & Therapy, 2021
Background β-amyloid (Aβ) and tau positron emission tomography (PET) detect the pathological changes that define Alzheimer’s disease (AD) in living people.
Elena Tsoy, Amelia Strom, Leonardo Iaccarino, Sabrina J. Erlhoff, Collette A. Goode, Anne-Marie Rodriguez, Gil D. Rabinovici, Bruce L. Miller, Joel H. Kramer, Katherine P. Rankin, Renaud La Joie, Katherine L. Possin   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Tourism as Memory-Making

Until recently the Russian Federation used to be one of the largest markets for outbound travel. Among Russians’ favourite destinations were cities that used to be part of the Russian Empire and the Soviet Union, and are now located in the independent ...
Pfoser, Alena
core   +1 more source

Trickbox of Memory

, 2020
"Reach into this trickbox of memory and rummage around: you may find a tiny spaceship, or perhaps a signpost, a parade, a raised fist, an entire museum. The essays in Trickbox of Memory: Essays on Power and Disorderly Pasts draw on literary criticism,

core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Problems Facing Disabled People in Malawi : A Critical Reflection on My Encounter with a Disabled Woman in a Rural Area in Malawi

Journal of Comparative Social Work, 2015
This critical reflection is based on my encounter with a disabled woman in a district in Malawi, and how I have reflected and analyzed the encounter using social work theories.
Memory J. Tembo
doaj  

Suppressing Non-Ideal Resonance in Defected Ground Structure Based on Grounded Coplanar Waveguide

IEEE Access
In this paper, a new method is proposed and verified to eliminate the non-ideal resonance caused by DGS application in GCPW by adding via holes to reduce electromagnetic leakage.
Tiansheng Ge, Binglin Cheng, Xu Han, Yaxin Chen, Hanbin Wang, Jun Zhang, Lin Lv, Li Tao, Wenjing Dong, Houzhao Wan, Guokun Ma, Yiheng Rao, Hao Wang   +12 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Externalising the autobiographical self: sharing personal memories online facilitated memory retention

, 2017
Internet technology provides a new means of recalling and sharing personal memories in the digital age. What is the mnemonic consequence of posting personal memories online?
Hou, Yubo, Wang, Qi, Lee, Dasom
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source