Results 71 to 80 of about 947,925 (355)

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

A consistent map in the medial entorhinal cortex supports spatial memory

Nature Communications
The medial entorhinal cortex (MEC) is hypothesized to function as a cognitive map for memory-guided navigation. How this map develops during learning and influences memory remains unclear. By imaging MEC calcium dynamics while mice successfully learned a
Taylor J. Malone, Nai-Wen Tien, Yan Ma, Lian Cui, Shangru Lyu, Garret Wang, Duc Nguyen, Kai Zhang, Maxym V. Myroshnychenko, Jean Tyan, Joshua A. Gordon, David A. Kupferschmidt, Yi Gu   +12 more
doaj   +1 more source

Attitudes toward clinical trials across the Alzheimer’s disease spectrum

Alzheimer’s Research & Therapy, 2017
Background Research has revealed that manifest Alzheimer’s disease (AD) dementia is preceded by preclinical and prodromal phases during which pathology is accumulating but function remains intact.
Michelle M. Nuño, Daniel L. Gillen, Kulwant K. Dosanjh, Jenny Brook, David Elashoff, John M. Ringman, Joshua D. Grill   +6 more
doaj   +1 more source

Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory [PDF]

, 2016
Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial ...
Abel, Ted, Baillie, George W., Bruinenberg, Vibeke M., Guercio, Leonardo A., Hansen, Rolf T., Havekes, Robbert, Houslay, Miles D., Lee, Yool, Linton, Edward, Meerlo, Peter, Neves, Susana R., Park, Alan J., Tolentino, Rosa E., Tudor, Jennifer C.   +13 more
core   +5 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

A comprehensive investigation of memory impairment in attention deficit hyperactivity disorder and oppositional defiant disorder [PDF]

, 2012
We conducted a comprehensive and systematic assessment of memory functioning indrug-naïve boys with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD).
Alloway, American Psychiatric Association, Baddeley, Baddeley, Baddeley, Baddeley, Barkley, Bayliss, Cannon, Castellanos, Coghill, Coghill, Cowan, Dunn, D’Esposito, Faraone, Gathercole, Gibson, Happé, Holmes, Holmes, Jarrold, Jarvis, Karatekin, Kaufman, Kempton, Kim, Kline, Klingberg, Krauel, Luciana, Martinussen, Martinussen, Matthews, Morris, Narhi, Oosterlaan, Oosterlaan, Pennington, Rhodes, Rhodes, Rhodes, Rhodes, Rubia, Scheres, Schneider, Shue, Skowronek, Swanson, Teichner, Toren, Unsworth, Van Goozen, Verte, Willcutt, Willcutt   +55 more
core   +1 more source

Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24 weeks.
Peiyu Wang, Lu Lu, Hui Gao, Qi Zhang, Jing Xiao, Josemir W. Sander, Weixi Xiong, Dong Zhou   +7 more
wiley   +1 more source

Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor

Alzheimer’s Research & Therapy
We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve ...
Joshua D. Grill, Daniel Gillen
doaj   +1 more source

Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals

Behavioural Neurology, 2009
Alzheimer’s disease (AD) is the most common form of dementia in old age, and is characterized by prominent impairment of episodic memory. Recent functional imaging studies in AD have demonstrated alterations in a distributed network of brain regions ...
Maija Pihlajamäki, Reisa A. Sperling
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source