Results 61 to 70 of about 948,328 (207)

Aging exacerbates development of cerebral microbleeds in a mouse model

Journal of Neuroinflammation, 2018
Background Cerebral microhemorrhages (CMH) are commonly found in the aging brain. CMH are also the neuropathological substrate of cerebral microbleeds (CMB), demonstrated on brain MRI. Recent studies demonstrate the importance of systemic inflammation in
Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Annlia Paganini-Hill, Kelley Kilday, Ronald Kim, David H. Cribbs, Mark J. Fisher   +7 more
doaj   +1 more source

Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor

Alzheimer’s Research & Therapy
We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve ...
Joshua D. Grill, Daniel Gillen
doaj   +1 more source

Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals

Behavioural Neurology, 2009
Alzheimer’s disease (AD) is the most common form of dementia in old age, and is characterized by prominent impairment of episodic memory. Recent functional imaging studies in AD have demonstrated alterations in a distributed network of brain regions ...
Maija Pihlajamäki, Reisa A. Sperling
doaj   +1 more source

Sleep quality influences subsequent motor skill acquisition [PDF]

, 2016
While the influence of sleep on motor memory consolidation has been extensively investigated, its relation to initial skill acquisition is less well understood.
Albouy, Genevieve, Appleman, Erica R., Cronin-Golomb, Alice, Doyon, Julien, King, Bradley R.   +4 more
core   +1 more source

Order and disorder in everyday action: the roles of contention scheduling and supervisory attention [PDF]

, 2002
This paper describes the contention scheduling/supervisory attentional system approach to action selection and uses this account to structure a survey of current theories of the control of action.
Cooper, Richard P.
core   +1 more source

The spotlight effect and the illusion of transparency in social anxiety [PDF]

, 2006
[Clark, D. M., & Wells, A. (1995). A cognitive model of social phobia. In: R. G. Heimberg, M. R. Liebowitz, D. A. Hope, & F. R. Schneier (Eds.), Social phobia: diagnosis, assessment, and treatment (pp. 69–93). New York: Guildford Press] cognitive
Abbot, Alden, American Psychiatric Association, Beck, Buss, Bögels, Carleton, Clark, Clark, Coles, Collins, Duke, Gilovich, Gilovich, Govern, Harvey, Hofmann, Hope, Kenny, Leary, Lusia Stopa, Mansell, McEwan, Mellings, Michael A. Brown, Rapee, Rapee, Rodebaugh, Savitsky, Stopa, Storch, Turk, Vorauer, Watson, Weeks, Wells, Whisman, Woody, Woody, Woody   +39 more
core   +1 more source

Memory, learning and language in autism spectrum disorder [PDF]

, 2018
Background and aims: The ‘dual-systems’ model of language acquisition has been used by Ullman and colleagues to explain patterns of strength and weakness in the language of higher-functioning people with autism spectrum disorder (ASD).
Bodison S., Boucher J., Bowler D., Fay W., Kim S. H., Mottron L., Prévost P., Tager-Flusberg H., Travers B. G., Wing L.   +9 more
core   +2 more sources

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis

Alzheimer’s Research & Therapy
Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined the role of CatD ...
Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring   +9 more
doaj   +1 more source

A novel de novo nonsense mutation in ZC4H2 causes Wieacker‐Wolff Syndrome

Molecular Genetics & Genomic Medicine, 2020
Background Wieacker‐Wolff syndrome (WWS) is a congenital X‐linked neuromuscular disorder, which was firstly reported in 1985. Zinc finger C4H2‐type containing (ZC4H2) gene has been found to be associated with the disease pathogenesis.
Dan Wang, Dongjie Hu, Zhichao Guo, Rong Hu, Qunxian Wang, Yannan Liu, Mingjing Liu, Zijun Meng, Huan Yang, Yun Zhang, Fang Cai, Weihui Zhou, Weihong Song   +12 more
doaj   +1 more source

Association between periodontal disease and age-related cognitive impairment: a narrative review

BMC Oral Health
Background Previous studies have shown associations between periodontal disease and age-related cognitive impairment. However, little is known about the different cognitive functions that may be affected in patients with periodontal disease.
Naoki Saji, Kenji Matsushita, Akinori Takeda, Takashi Sakurai   +3 more
doaj   +1 more source