Results 61 to 70 of about 470,574 (313)

Attitudes toward clinical trials across the Alzheimer’s disease spectrum

Alzheimer’s Research & Therapy, 2017
Background Research has revealed that manifest Alzheimer’s disease (AD) dementia is preceded by preclinical and prodromal phases during which pathology is accumulating but function remains intact.
Michelle M. Nuño, Daniel L. Gillen, Kulwant K. Dosanjh, Jenny Brook, David Elashoff, John M. Ringman, Joshua D. Grill   +6 more
doaj   +1 more source

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia

Signal Transduction and Targeted Therapy, 2021
Increased endogenous hydrogen sulfide (H2S) level by cystathionine β-synthase (CBS) has been shown to closely relate tumorigenesis. H2S promotes angiogenesis, stimulates bioenergy metabolism and inhibits selective phosphatases.
Dan Wang, Huan Yang, Yun Zhang, Rong Hu, Dongjie Hu, Qunxian Wang, Yannan Liu, Mingjing Liu, Zijun Meng, Weihui Zhou, Weihong Song   +10 more
doaj   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Aging exacerbates development of cerebral microbleeds in a mouse model

Journal of Neuroinflammation, 2018
Background Cerebral microhemorrhages (CMH) are commonly found in the aging brain. CMH are also the neuropathological substrate of cerebral microbleeds (CMB), demonstrated on brain MRI. Recent studies demonstrate the importance of systemic inflammation in
Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Annlia Paganini-Hill, Kelley Kilday, Ronald Kim, David H. Cribbs, Mark J. Fisher   +7 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals

Behavioural Neurology, 2009
Alzheimer’s disease (AD) is the most common form of dementia in old age, and is characterized by prominent impairment of episodic memory. Recent functional imaging studies in AD have demonstrated alterations in a distributed network of brain regions ...
Maija Pihlajamäki, Reisa A. Sperling
doaj   +1 more source

Stratified medicine for mental disorders [PDF]

, 2014
There is recognition that biomedical research into the causes of mental disorders and their treatment needs to adopt new approaches to research. Novel biomedical techniques have advanced our understanding of how the brain develops and is shaped by ...
Meyer-Lindenberg, Andreas, Stephani, Klaas E., Haro, J.M., Frith, Chris D., de Kloet ER, Lewis, S, Vieta E, Ciccocioppo, R., Flor, Herta, Vieta, Eduard, Schumann, G., Brown, Verity J., Nutt, DJ, Kirschbaum, C, Cools R, de Kloet, E Ronald, Roiser, JP., Müller, Christian P, Holte, A, Müller, W.E., Martinot JL, Walker-Tilley, TR, Nutt, D., Heinz, A., Bitter I, Martinot, J-L, Müller, Walter E., Roiser, JP, Wykes T, Walker Tilley TR, Lesch, K., Pessiglione, M, Lewis, Shon, Lesch, K.P., Wittchen HU, Maria Haro, J., Walker-Tilley, Tom R, Mueller, Walter E., Oedegaard, K.J., Haro JM, Sandi, C, Robbins, Trevor W, Fleischhacker, W, Holte, A., Maier, Wolfgang, Oedegaard, K., Robbins, T.W., Buitelaar J, Preuss, Ulrich W., Perugi, G, Flor, H., Rybakowski, Janusz, Persico, A., Binder, Elisabeth B., Roiser, J., de Kloet, E.R., Müller, C.P., Haro, Josep Maria, Rossini, Paolo M., Schumann, Gunter, Johnsen, Erik, Roiser, Jonathan P, Schumann, G, Sandi, Carmen, Ciccocioppo R, Escera, C., Oedegaard, KJ, Nutt, David J, Binder, Elizabeth B., Perugi, Giulio, Brown, Verity J, Martinot, JL., Lewis, S., Wittchen, H., Müller, Walter E, Fleischhacker, Wolfgang W., Flor H, Cools, R., Lewis S, Rossini, P.M., Rybakowski, Janusz K., Stephan, K.E., Escera, Carles, Lesch, K.-P., Wittchen, Hans Ulrich, Klingberg, Torkel, Maier, W., Wykes, T., Lesch KP, Walker-Tilley, Tom R., Walker-Tilley, T., Heinz A, Holte, Arne, van der Wee N, Wittchen, HU, Stephan KE, Meyer-Lindenberg A, Meyer-Lindenberg, A., Maier W, Binder EB, Oedegaard, Ketil J, van der Wee, N., Nutt, David J., Undurraga, J., Pessiglione, M., Binder, Elisabeth B, Lewis, Shon; id_orcid, et al, Wittchen, Hans-Ulrich, Flor, H, Nutt DJ, Pessiglione, Mathias, Mueller, CP, Lesch, KP., Ciccocioppo, R, Heinz, A, Binder, E.B., Frith, C.D., Buitelaar, Jan, Oedegaard KJ, Nutt, D.J., Rybakowski, J.K., CICCOCIOPPO, Roberto, Rybakowski, J., Walker-Tilley TR, Johnsen E, Perugi, G., Rybakowski, Janusz K, Mueller, C., Brown, V.J., Lesch, K-P, Roiser, Jonathan P., Persico, Antonio, Johnsen, E, Rybakowski, JK, Martinot, J.L., van der Wee, Nic, Wykes, Til, Preuss, U.W., Wittchen, H.U., Müller, CP., Preuss, U., Rybakowski JK, Sandi C, M?ller CP, Stephan, K., Brown VJ, de Kloet, E. Ronald, Rossini PM, Rybakowski, JK., Wee, N. van der, Pessiglione M, Rossini, PM., Wittchen, HU., Roiser JP, Cools, Roshan, Persico, A, Stephan, KE, Rossini, Paolo M, Wykes, T, Frith, C., Mueller, W., Kloet, E.R. de, Klingberg, T, Maria Haro, Josep, Undurraga J, Mann, K, Robbins TW, Maier, W, Frith CD, Preuss, UW, Buitelaar, J.K., Buitelaar, J., Mann K, van der Wee, N, Buitelaar, J, Sandi, C., Muller WE, Preuss, Ulrich W, Meyer-Lindenberg, A, Müller, WE., Escera, C, Stephan, Klaas E., Perugi, Guilio, de Kloet, ER, Oedegaard, Ketil J., de Kloet, E. R., Escera C, Kirschbaum, Clemens, Wee, N.J.A. van der, Bitter, István, Stephan, KE., Bitter, I., Klingberg T, Mueller, WE, Meyer Lindenberg A, Robbins, Trevor W., Binder, E., Lesch, Klaus-Peter, Johnsen, E., Holte A, de Kloet, E., Cools, R, Undurraga, J, Frith, CD, Undurraga, Juan, Nutt, DJ., Martinot, J., Martinot, J.-L., Robbins, T., Maria Haro, J, Rossini, Paolo Maria, Mann, Karl, Schumann G, Frith, Chris D, Binder, EB, Stephan, Klaas E, Fleischhacker, W., Rossini, PM, Martinot, Jean-Luc, Mueller, Christian P., Bitter, I, Walker-Tilley, T.R., Müller, Christian P., Klingberg, T., Heinz, Andreas, Brown, VJ, Persico A, Brown, V., Kirschbaum, C., Muller CP, Vieta, E., Fleischhacker W, Preuss, UW., M?ller WE, Robbins, TW, Rossini, P., Mann, K., Vieta, E, Kirschbaum C, Wykes, Til; id_orcid, Roiser, J.P., Fleischhacker, Wolfgang, Haro, JM., Perugi G, Preuss UW   +245 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

The role of thyroid hormones in Alzheimer's disease: Associations with cerebrospinal fluid biomarkers and diagnostic performance

Journal of Alzheimer's Disease Reports
Background The relationship between serum thyroid function indicators and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathology, as well as their diagnostic value in dementia differentiation, remains poorly understood in individuals ...
Yazhen Huang, Meina Quan, Qianqian Wang, Junhua Liang, Tingting Li, Wei Wang   +5 more
doaj   +1 more source