Results 61 to 70 of about 3,905,908 (191)

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis

Alzheimer’s Research & Therapy
Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined the role of CatD ...
Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring   +9 more
doaj   +1 more source

A novel de novo nonsense mutation in ZC4H2 causes Wieacker‐Wolff Syndrome

Molecular Genetics & Genomic Medicine, 2020
Background Wieacker‐Wolff syndrome (WWS) is a congenital X‐linked neuromuscular disorder, which was firstly reported in 1985. Zinc finger C4H2‐type containing (ZC4H2) gene has been found to be associated with the disease pathogenesis.
Dan Wang, Dongjie Hu, Zhichao Guo, Rong Hu, Qunxian Wang, Yannan Liu, Mingjing Liu, Zijun Meng, Huan Yang, Yun Zhang, Fang Cai, Weihui Zhou, Weihong Song   +12 more
doaj   +1 more source

Association between periodontal disease and age-related cognitive impairment: a narrative review

BMC Oral Health
Background Previous studies have shown associations between periodontal disease and age-related cognitive impairment. However, little is known about the different cognitive functions that may be affected in patients with periodontal disease.
Naoki Saji, Kenji Matsushita, Akinori Takeda, Takashi Sakurai   +3 more
doaj   +1 more source

Transcriptional activation of USP16 gene expression by NFκB signaling

Molecular Brain, 2019
Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely unknown. To study the mechanism underlying USP16 gene expression, USP16 gene promoter
Shou Yang, Juelu Wang, Shipeng Guo, Daochao Huang, Isabel Bestard Lorigados, Xing Nie, Dandan Lou, Yanhua Li, Mingjing Liu, Yu Kang, Weihui Zhou, Weihong Song   +11 more
doaj   +1 more source

Memory and memory disorders: Neuroimaging correlates of organic damage and psychic disorders

, 2004
Markowitsch HJ. Memory and memory disorders: Neuroimaging correlates of organic damage and psychic disorders. INTERNATIONAL JOURNAL OF PSYCHOLOGY.
Markowitsch, Hans J.
core  

Aging and visual feature binding in working memory [PDF]

, 2013
This chapter examines the question of how the features or elements (e.g. shape, color, or spatial location) of a stimulus that is encountered in the visual environment are bound together in working memory to form an integrated representation.
Niven, Elaine, Brown, Louise A., Allen, Richard J.   +2 more
core   +3 more sources

Factors associated with perceived work ability among people working one year after stroke: an exploratory cross-sectional study

Journal of Rehabilitation Medicine
Objective: Knowledge of factors contributing to sustained work ability after stroke is limited. This study explored the association between perceived work ability and personal, stroke-related and work-related factors.
Ingrid Lindgren, Anna Norlander, Hélène Pessah-Rasmussen, Christina Brogårdh   +3 more
doaj   +1 more source

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

Neurobiology of Disease, 2014
Synapse number is the best indicator of cognitive impairment In Alzheimer's disease (AD), yet the respective contributions of Aβ and tau, particularly human wild-type tau, to synapse loss remain undefined.
Meredith A. Chabrier, David Cheng, Nicholas A. Castello, Kim N. Green, Frank M. LaFerla   +4 more
doaj   +1 more source

High pulse wave velocity is associated with enlarged perivascular spaces in dementia with Lewy bodies

Scientific Reports
Previous studies have demonstrated associations between enlarged perivascular spaces (EPVS) and dementias such as Alzheimer’s disease. However, an association between EPVS and dementia with Lewy bodies (DLB) has not yet been clarified.
Naoki Saji, Yoshino Kinjo, Kenta Murotani, Shumpei Niida, Akinori Takeda, Takashi Sakurai   +5 more
doaj   +1 more source

Disorders of working memory and selected cognitive processes inpatients treated for paranoid schizophrenia [PDF]

, 2012
Already since the times of Baddeley and Hitch the dorsolateral part of the frontal lobe was regarded as the function‑ al centre of the working memory. Working memory disorders are, on the other hand, one of the basic and consoli‑ dated disorders in the
Damian Giętkowski, Giętkowski, Damian
core